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J Exp Biol (2022) 225 (1): jeb229542.
Published: 4 January 2022
... comprehensively researched, the role of the nervous system in this process remains relatively underexplored. In this Review, we adopt the perspective that the nervous system plays an active, essential role in facilitating and supporting hibernation. Accumulating evidence strongly suggests that the hypothalamus...
Cristina Velasco, Marta Conde-Sieira, Sara Comesaña, Mauro Chivite, Jesús M. Míguez, José L. Soengas
J Exp Biol (2021) 224 (13): jeb242360.
Published: 2 July 2021
..., we assessed the effects on food intake of intracerebroventricular treatment with agonists of these receptors. In the second experiment, we assessed the impact of the same treatments on mRNA abundance in the hypothalamus and hindbrain of neuropeptides involved in the metabolic control of food intake...
Includes: Supplementary data
J Exp Biol (2020) 223 (24): jeb236109.
Published: 21 December 2020
... into the migratory phenotype. This was evidenced by post-mortem comparison of the expression of 13 genes with known functions in the skin (temperature-sensitive TRP channels: trpv4 and trpm8 ), hypothalamus and/or midbrain (migration-linked genes: th , ddc , adcyap1 and vps13a ) and flight muscles (muscle growth...
Includes: Supplementary data
J Exp Biol (2020) 223 (17): jeb221721.
Published: 6 September 2020
... in hypothalamus 10–30 min after oral treatment with amino acids. In particular, proline induced changes consistent with an increased anorexigenic potential in the hypothalamus. We have therefore demonstrated, for the first time in fish, that the peripheral (pre-absorptive) detection of an amino acid ( l -proline...
Cristina Velasco, Marta Conde-Sieira, Sara Comesaña, Mauro Chivite, Adrián Díaz-Rúa, Jesús M. Míguez, José L. Soengas
J Exp Biol (2020) 223 (17): jeb227330.
Published: 3 September 2020
... of food intake, such as hypothalamus and hindbrain, we have obtained evidence for a fatty acid-sensing role for FFA1 and FFA4. The i.c.v. treatment with agonists of these receptors elicited an anorectic response in rainbow trout attributable to changes observed in the mRNA abundance of neuropeptides npy...
J Exp Biol (2020) 223 (8): jeb213454.
Published: 23 April 2020
...Ayelén M. Blanco; Juan I. Bertucci; José L. Soengas; Suraj Unniappan ABSTRACT This research assessed the direct effects of insulin on nutrient-sensing mechanisms in the brain of rainbow trout ( Oncorhynchus mykiss ) using an in vitro approach. Cultured hypothalamus and hindbrain were exposed to 1...
Includes: Supplementary data
J Exp Biol (2019) 222 (10): jeb198424.
Published: 29 May 2019
...Hossein Shirvani; Saleh Rahmati-Ahmadabad; David Robert Broom; Reza Mirnejad ABSTRACT The hypothalamus controls metabolism and feeding behaviour via several signals with other tissues. Exercise and supplements can change hypothalamic signalling pathways, so the present study investigated...
Cristina Velasco, Guillermo Moreiras, Marta Conde-Sieira, José M. Leao, Jesús M. Míguez, José L. Soengas
J Exp Biol (2017) 220 (14): 2563–2576.
Published: 15 July 2017
..., in a first experiment, we observed that ceramide levels in the hypothalamus of rainbow trout did not change after ICV treatment with GHRL. In a second experiment, we assessed whether the effects of GHRL treatment on the regulation of food intake in rainbow trout changed in the presence of ceramide. Thus, we...
J Exp Biol (2017) 220 (4): 607–614.
Published: 15 February 2017
... or financial interests. 2 6 2016 23 11 2016 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Hypothalamus-based self-adjustment in response to dietary fat can vary among lean and fat individuals, and depends upon whole...
J Exp Biol (2016) 219 (24): 3861–3865.
Published: 15 December 2016
... type-2-like receptor (D2R)-mediated inhibition within the hypothalamus. These results suggest that direct dopaminergic control of GnRH1 neurons via interactions in the hypothalamus is not exclusive to tetrapod reproductive control, but is likely conserved across vertebrate species. * Author...
Includes: Supplementary data
J Exp Biol (2016) 219 (21): 3353–3365.
Published: 1 November 2016
.... In GDX males, low expression of kiss1 mRNA is observed by in situ hybridization in the caudal hypothalamus (CH) and the mediobasal hypothalamus (MBH), although hypothalamic changes in kiss1 mRNA levels were not statistically different among the groups, as revealed by real-time PCR. However, T strongly...
Cristina Otero-Rodiño, Cristina Velasco, Rosa Álvarez-Otero, Marcos A. López-Patiño, Jesús M. Míguez, José L. Soengas
J Exp Biol (2016) 219 (11): 1750–1759.
Published: 1 June 2016
... and hyperglycaemic treatments) of glucosensing mechanisms based on liver X receptor (LXR), mitochondrial production of reactive oxygen species (ROS) leading to increased expression of uncoupling protein 2 (UCP2), and sweet taste receptor in the hypothalamus, and on sodium/glucose co-transporter 1 (SGLT-1...
Angelico Madaro, Rolf E. Olsen, Tore S. Kristiansen, Lars O. E. Ebbesson, Tom O. Nilsen, Gert Flik, Marnix Gorissen
J Exp Biol (2015) 218 (16): 2538–2550.
Published: 1 August 2015
... stressor (UCS) paradigm, which mimics the effects of multiple stressors, causes dynamic changes at every level of the hypothalamic–pituitary gland–interrenal gland (HPI) axis of Atlantic salmon parr. Salmo salar Parr Cortisol HPI axis crf Gene study Brain Hypothalamus Pituitary gland...
J Exp Biol (2015) 218 (10): 1521–1526.
Published: 15 May 2015
... the retinohypothalamic tract, which transmits light information to the suprachiasmatic nucleus in the hypothalamus. However, it has been shown that light penetrates the skull. Here, we present the effect of transcranial light treatment on OPN3 expression and monoamine concentrations in mouse brain and other tissues...
J Exp Biol (2014) 217 (1): 102–108.
Published: 1 January 2014
... in the hypothalamus. In particular, we focus on signalling via endocannabinoids and describe plasticity in this system that impacts fast retrograde signalling at synapses on to the stress command neurons in the brain. Interestingly, this plasticity appears to be limited to early adolescence, hinting at unique modes...
Noah T. Ashley, James C. Walton, Achikam Haim, Ning Zhang, Laura A. Prince, Allison M. Fruchey, Rebecca A. Lieberman, Zachary M. Weil, Ulysses J. Magalang, Randy J. Nelson
J Exp Biol (2013) 216 (14): 2581–2586.
Published: 15 July 2013
... later. LPS increased liver and hypothalamic interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF) gene expression compared with vehicle. Among LPS-challenged hamsters, sleep deprivation reduced IL-1 mRNA levels in liver and hypothalamus, but not TNF. IL-1 attenuation was independent of circulating...
J Exp Biol (2012) 215 (17): 3112–3119.
Published: 1 September 2012
...Marta Conde-Sieira; Marcos A. López Patiño; Jesús M. Míguez; José L. Soengas SUMMARY To assess whether the glucosensing capacity in peripheral (liver and Brockmann bodies) and central (hypothalamus and hindbrain) locations of rainbow trout displays day–night variations in its response to changes...
J Exp Biol (2011) 214 (22): 3887–3894.
Published: 15 November 2011
...Marta Conde-Sieira; Marta Librán-Pérez; Marcos A. López Patiño; Jesús M. Míguez; José L. Soengas SUMMARY Stress conditions induced in rainbow trout a readjustment in the glucosensing response of the hypothalamus and hindbrain such that those sensors did not respond properly to changes in glucose...
Marta Conde-Sieira, Maria J. Agulleiro, Ariel J. Aguilar, Jesús M. Míguez, José M. Cerdá-Reverter, José L. Soengas
J Exp Biol (2010) 213 (22): 3858–3865.
Published: 15 November 2010
...) and anorexigenic (POMC, CART and CRF) peptides in central glucosensing areas (hypothalamus and hindbrain) of rainbow trout subjected to normoglycaemic (control), hypoglycaemic (4 mg insulin kg –1 ) or hyperglycaemic (500 mg glucose kg –1 ) conditions for 6 h under normal stocking density (NSD; 10 kg fish mass m –3...
J Exp Biol (2009) 212 (18): 2885–2891.
Published: 15 September 2009
... regulatory pathways as adaptive thermogenesis in endotherms. Both groups rely on transient receptor potential ion channels to sense environmental temperatures. Thermosensory (afferent) information is relayed to the hypothalamus, which initiates a sympathetic efferent response. Cardiovascular responses...