...Keith Munson; Nils Lambrecht; Jai Moo Shin; George Sachs ABSTRACT A structure of the catalytic or alpha subunit of the H + /K + -ATPase, with ten transmembrane segments, and of the beta subunit, with a single such segment, was established using a combination of tryptic cleavage and peptide...

... of inhibitors of H + /K + -ATPases, including omeprazole and SCH 28080, suggest that a pump similar to the H + /K + -ATPase of the gastric mucosa is involved in KCl reabsorption. The presence of K + channels in the basolateral membrane in the lower Malpighian tubule is suggested by inhibition of KCl...

... to be totally insensitive to ouabain but sensitive to amiloride. Application of the H + /K + -ATPase-specific inhibitor SCH 28080 suggested the presence of an H + /K + pump similar to the mammalian gastric H + /K + -ATPase in the lepidopteran muscles. P. terraenovae muscles, however, were found to be totally...

...Masatomo Maeda; Kentaro Kubo; Tsuyoshi Nishi; Masamitsu Futai ABSTRACT The gastric H + /K + -ATPase is a P-type ATPase that is specifically expressed in gastric parietal cells and is responsible for acid secretion into the stomach. We have found one or more gastric mucosal nuclear proteins...