... challenges and exciting opportunities for the future of experimental biology. Biologgers Genomics Bioengineering Modeling Simulations Field physiology Individual variation Over the 100 years that Journal of Experimental Biology (JEB) has been in existence, much has changed – from the ways...

..., such investigations often rely on receptor subtype-specific pharmacological agents (agonists and antagonists; see Glossary) developed and validated in mammals. Meanwhile, evolutionary (phylogenetic and comparative genomic) studies have begun to unravel the diversification of adrenergic receptors (ARs) and reveal...

.... Transcriptomics Metabolomics Genomics RNA-seq Hypothesis testing A goal of comparative physiology is to understand the diverse mechanisms that allow animals to function and survive in their environments. Comparative physiologists (1) inquire vertically across levels of biological organization, (2...

..., suggesting an epigenetic control of their migration. The genes and epigenetic changes underpinning migratory behaviour remain largely unknown. The revolution in (epi)genomics and functional genomic tools holds great promise to rapidly move the field of migration genetics forward. Here, we review our current...

... in aggression in the honey bee. Behavioral plasticity Genomics Neural energetics Alzheimer's disease Traumatic brain injury References Alaux , C. , Sinha , S. , Hasadsri , L. , Hunt , G. J. , Guzmán-Novoa , E. , Degrandi-Hoffman , G. , Uribe-Rubio , J. L...

... ). Genomic reaction norms: using integrative biology to understand molecular mechanisms of phenotypic plasticity . Mol. Ecol.   18 , 3763 - 3780 . 10.1111/j.1365-294X.2009.04313.x Belinky , F. , Nativ , N. , Stelzer , G. , Zimmerman , S. , Iny Stein , T. , Safran , M...

... at a molecular level; however, recent progress on sequencing technology and genome editing tools have begun to blur the lines between model and non-model organisms, opening numerous new avenues for investigation. Here, I review examples of epigenetic phenomena in non-model organisms that have emerged...

... the paper. COMPETING INTERESTS No competing interests declared. 24 2 2013 17 5 2013 © 2013. Published by The Company of Biologists Ltd 2013 genomics microarrays social evolution nest initiation A common feature of animal societies is social regulation, where...

... is monitoring for changes in their phototactic behavior. In most arthropods, histamine has been shown to play a key role in the visual system. Currently, nothing is known about histaminergic signaling in either D. magna or D. pulex . Here, a combination of immunohistochemistry and genome mining was used...

... by microarray analysis. * Author for correspondence (e-mail: [email protected] ) 18 9 2008 © The Company of Biologists Limited 2008 2008 fish genomics Gillichthys mirabilis microarray osmotic salinity signaling stress transcriptome Osmolality is a pervasive abiotic...

... to combining genomic and physiological studies, one must bear in mind that the massive datasets associated with genomic studies need to be further enlarged to enable estimates of individual variation. It is also important to remember that microarray and proteomic data give the levels of mRNA and proteins...

...Piero Carninci SUMMARY The principal route to understanding the biological significance of the genome sequence comes from discovery and characterization of that portion of the genome that is transcribed into RNA products. We now know that this`transcriptome' is unexpectedly complex and its precise...

...Stuart K. Kim SUMMARY Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many...

... multi-component systems. Systems biology has emerged in the post-genome era as the successor to reductionism. In my opinion, systems biology and physiology are synonymous. Both disciplines seek to understand multi-component processes or `systems' and the underlying pathways of information flow from...

... Biol . 5 , 355 -366. Cossins, A. R. and Crawford, D. L. ( 2005 ). Fish as models for environmental genomics. Nat. Rev. Genet. 6 , 324 -340. Di Ciano, C., Nie, Z., Szaszi, K., Lewis, A., Uruno, T., Zhan,X., Rotstein, O. D., Mak, A. and Kapus, A. ( 2002 ). Osmotic stress-induced...

... (transmission blocking vaccines), genetic manipulation or chemical incapacitation of the vector. During the past decade, mosquito research has been energized by several breakthroughs, including the successful transformation of anopheline vectors, analysis of gene function by RNAi,genome-wide expression...

...D. L. Doolan; J. C. Aguiar; W. R. Weiss; A. Sette; P. L. Felgner; D. P. Regis; P. Quinones-Casas; J. R. Yates, III; P. L. Blair; T. L. Richie; S. L. Hoffman; D. J. Carucci SUMMARY Recent advances in the fields of genomics, proteomics and molecular immunology offer tremendous opportunities...

... salivary gland malaria proteomics transcriptome genomics blood-sucking insect Malaria affects 200 million people worldwide and causes approximately 1.5 million deaths every year ( Fauci,2001 ). The disease is caused by Plasmodium parasites transmitted by the blood-sucking mosquito...