...Benjamin N. Harwood; Isabelle Draper; Alan S. Kopin Bursicon is a hormone that modulates wing expansion, cuticle hardening and melanization in Drosophila melanogaster . Bursicon activity is mediated through its cognate G protein-coupled receptor (GPCR), rickets. We have developed a membrane...

... cyclase is typical of cells expressing a constitutively active Gi/o-coupled receptor( Johnston and Watts, 2003 ). Constitutive activity has been observed in mammalian 5-HT 1 receptors as well as other G protein-coupled receptors( Berg et al., 2005 ; Cosi and Koek, 2000 ; Johnston and Watts, 2003 ; Liu...

...Erik C. Johnson; Orie T. Shafer; Jennifer S. Trigg; Jae Park; David A. Schooley; Julian A. Dow; Paul H. Taghert SUMMARY The Drosophila orphan G protein-coupled receptor encoded by CG17415 is related to members of the calcitonin receptor-like receptor (CLR) family. In mammals, signaling from CLR...

... hybridisation also indicated the predominant expression of these genes in the eyestalk. Analysis of the putative protein sequences showed that they contained two transmembrane (TM) helices, a short amino acid sequence sharing high homology with the G-protein-coupled receptor (GPCR) motif in the second TM...