... of activation. One hypothesis proposed to account for these force depression (FD) and force enhancement (FE) properties is a change in cross-bridge cycling kinetics. The rate of cross-bridge attachment ( f ) and/or cross-bridge detachment ( g ) may be altered following active shortening and active stretching...

... deletion exhibit large deficits in net negative work, suggesting that titin contributes to energy storage and dissipation during stretch–shortening cycles. Energy storage and dissipation Force enhancement Force depression Negative work Muscular dystrophy with myositis Titin/connectin...

...Venus Joumaa; Alex Fitzowich; Walter Herzog ABSTRACT The steady-state isometric force after active shortening of a skeletal muscle is lower than the purely isometric force at the corresponding length. This property of skeletal muscle is known as force depression. The purpose of this study...