... induces contractions via a G-protein coupled FMRFamide receptor in muscle cells but does not appear to act via cAMP, cGMP, IP 3 , PLC, CaMKII or arachidonic acid. * Author for correspondence ( [email protected] ) Author contributions Conception and design of experiments, interpretation...

... as the FMRFamide-like peptide crustacean myosuppressin (Crust-MS). The modulatory effects of Crust-MS application on the gastric mill and pyloric patterns, generated in the stomatogastric ganglion (STG), closely resembled those recorded following extracellular PS neuron stimulation. To determine whether histamine...

...Daniel Kueh; John A. Jellies SUMMARY The heart excitor (HE) motor neuron in the leech Hirudo releases acetylcholine (ACh) and a peptide, FMRFamide, to regulate the contractile activity of the heart tube and associated side vessels. Consistent with Dale's principle, it was assumed that both...

... of momentary, isolated arrests of pre-oral cilia, but failed to suppress beating of the post-oral cilia at these concentrations. The neuropeptides, FMRFamide and Leu-enkephalin, did not affect the frequency of ciliary beating or of isolated ciliary arrests, but did induce numerous muscular contractions, which...

... with FMRFamide-like immunoreactivity. Application of food juices to sites on the margin and tentacles evoked trains of impulses in the axon bundles (F events; conduction velocity 15.5±3.7 cm s -1 ) and in the epithelium lining the radial canals (E events; conduction velocity 28.5±3.5 cm s -1 ). Impulses were...

... of the lower molecular masses observed. One conserved set of peaks corresponds to the FMRFamide-related peptides (FRPs). The Loligo opalescens FMRFa gene has been sequenced. It encodes a 331 amino acid residue prohormone that is processed into 14 FRPs, which are both predicted by the nucleotide sequence...

... locust Locusta migratoria L. Morphometric analysis of FMRFamide-like immunoreactivity was used as an indirect measure of the amount of FMRFamide-related peptides (FaRPs) stored in the gut endocrine cells. There was a highly significant correlation between FaRP content and the nutritional quality...

..., and the related molluscan tetrapeptide FMRFamide elicited only a modest inhibition of I sc . Mas-AT, F7G and F7D inhibited the I sc in a dose-dependent manner. Maximal inhibition of I sc by Mas-AT was achieved at a concentration of 50 nmol l −1 . At 100 nmol l −1 , Mas-AT produced a significantly greater...

...Kira J. Belkin; Thomas W. Abrams ABSTRACT The molluscan neuropeptide FMRFamide has a number of inhibitory actions on the sensory neurons and motoneurons mediating the defensive gill and siphon withdrawal reflex pathway of Aplysia californica. Exogenous application of FMRFamide has a biphasic, dual...

...Ann Jane Tierney; Jennifer Blanck; A. Joffre Mercier ABSTRACT Whole-mount immunocytochemistry was used to map the location of FMRFamide-like peptides in the crayfish ( Procambarus clarkii ) stomatogastric nervous system. This system contains the pyloric and gastric mill central pattern generators...

...Glen A. Cottrell ABSTRACT Patch-clamp experiments on the C2 neurone of Helix aspersa have shown that the neuropeptide Phe-Met-Arg-Phe-NH 2 (FMRFamide) directly gates a Na + channel. The channel is amiloride-sensitive. Activation of this channel is responsible for the fast excitatory action...

..., mosquito, adult moth and kissing bug. Their roles, although not fully elucidated, appear to be in the control of salivary secretion. Several peptides, including members of the FMRFamide-related family of peptides, are also found associated with insect salivary glands. Sources of peptidergic innervation...

...Poh Kheng Loi; Nathan Tublitz ABSTRACT The display of complex color patterns of the cuttlefish Sepia officinalis is under the regulation of the FMRFamide-related peptide (FaRP) family, but their exact identities are unknown. We report the isolation and characterization of a full-length FaRP cDNA...

... in the European cuttlefish Sepia officinalis are also regulated by the FMRFamide family of neuropeptides. Using an in vitro chromatophore bioassay, it has been determined that several FMRFamide-related peptides (FaRPs) are potent excitors of the chromatophore muscles, causing chromatophore expansion...

... and 100 mmol l −1 depending on the physiological state. The NNC contains FMRFamide in its soma and sensory terminals in the nephridium. Bath or focal application of FMRFamide leads to hyperpolarization and decreases the rate of firing of the NNC, suggesting autoregulation of peptide release. Experiments...

... the increase elicited by NF 1 appears to involve presynaptic and postsynaptic mechanisms. * Present address: School of Biological Sciences, Flinders University, Bedford Park, South Australia 5042, Australia. † Author for correspondence 23 8 1994 synaptic modulation FMRFamide...

...-phase high pressure liquid chromatography, radioimmunoassay and subsequent Edman degradation and mass spectrometry, authentic FMRFamide has been identified as the major peptide of the NNC. Sensory and neurosecretory innervation of the nephridia is thus accomplished by a single neurone, which is thought...

... chromatography and the fractions analysed by radioimmunoassay (RIA). The results indicate that ten cardioactive peptides, FMRFamide, FLRFamide, six FMRFamide-related heptapeptides and two nonapeptide analogues of the small cardioactive peptides (SCPs), are present in the circumoesophageal ganglia (brain...

...J. E. Richmond; L. R. Funte; W. L. Smith; D. A. Price; P. G. Haydon ABSTRACT We examined the synaptic connection between Phe-Met-Arg-Phe-NH 2 (FMRFamide)-immunoreactive neurone VD4 and its target neurone Pl, both found in the central nervous system of the pond snail Helisoma trivolvis . The major...

...A. Joffre Mercier; Ian Orchard; Victoria Tebrugge ABSTRACT FMRFamide-like immunoreactivity (FLI) was detected in the nervous system of the crayfish Procambarus clarkii using an antiserum that recognizes extended RFamide peptides. Immunocytochemistry revealed FLI in neuronal somata, axons...