... and Herzog, 2010 ; Nishikawa et al., 2012 ; Powers et al., 2014 , 2016 ). Eccentric contraction Passive tension Skeletal muscle Skinned fibres Summary: Titin force is differentially enhanced in skinned skeletal muscle fibres from control and titin-mutant mice. © 2017. Published...

... the properties of isometrically and concentrically contracting muscle, it has failed miserably in explaining experimental observations in eccentric contractions. Here, I suggest, and provide evidence, that a third filament, titin, is involved in force regulation of sarcomeres by adjusting its stiffness...

... test eccentric contraction lengthening It is well known that the steady-state isometric force generated by a muscle is higher after active stretch than during a purely isometric contraction at the same muscle length( Abbott and Aubert, 1952 ). Stretch has also been shown to increase force...