... filled with buffered NaCl (154 mmol l −1 plus 1 mmol l −1 HEPES) and bathed in mosquito saline with theophylline, fluid absorption was augmented (50.0±5.8 nl min −1 , N =12, ±s.e.m.). Concanamycin A (10 µmol l −1), ouabain (1 mmol l −1), and acetazolamide (1 mmol l −1) affected V te in different ways...

... hemolymph-like salines. Although hemolymph-side ouabain did not affect this current, concanamycin significantly reduced I sc without altering preparation conductance, suggesting V-ATPase-driven Cl – absorption on the distal side of the posterior gill lamellae, as known to occur in diadromous crabs adapted...

.... They have been implicated in a wide variety of cellular processes and are associated with several diseases. Bafilomycin and concanamycin, specific inhibitors of V-ATPases, have been instrumental in implicating the V-ATPase in many of these roles. To understand further the mechanism of inhibition...