... understood. One of the hallmarks of diapause is a massive slowdown in the cell cycle of target organs such as the brain and primordial imaginal structures, and resumption of cell cycle proliferation is an indication of diapause termination and resumption of development. Characterizing cell cycle parameters...

... repair capacity. It was previously shown that Spalax ’s unique p53 structure shifts the activation of its target genes by favoring DNA repair and cell cycle arrest over apoptotic gene activation (Shams et al., 2013 ; Avivi et al., 2007 ; Ashur-Fabian et al., 2004). This may provide Spalax...

..., was also detected in the gonad acini and duct cells, thus confirming that germline cells were abundant early on. In addition, the binding of the minichromosome maintenance MCM6 protein to chromatin indicated the gonad acini and duct cells were engaged in the cell cycle. DNA replication was indeed confirmed...

... reef sponge shows an extremely high proliferation activity, a short cell cycle duration and massive cell shedding. Cell turnover is predominantly confined to a single cell population, i.e. the choanocytes, and in this process apoptosis only plays a minor role. To our knowledge, such fast cell kinetics...

... suggests that elevated ecdysone may facilitate onset of diapause in A. socius . Upregulation seen for the transcription factors Reptin and TFDp2 may serve to depress transcription and cell cycle progression. Cathpesin B-like protease, ACLY and MSP are three downregulated genes associated with yolk...

... as cyclobutane pyrimidine dimer formation. Cells with DNA damage caused by ultraviolet radiation (UVR, 290-400 nm) and oxidative stress can survive, but are often retained in the G 1 /S phase of the cell cycle to repair DNA as a result of the expression of cell cycle genes such as p 53 and p 21...

...Julie C. Brodeur; Jorge Calvo; Andrew Clarke; Ian A. Johnston SUMMARY In teleosts, the proliferation of myogenic progenitor cells is required for muscle growth and nuclear turnover. We measured the cell cycle and S-phase duration of myogenic cells in the fast myotomal muscle of two closely related...

...Valery Filippov; Maria Filippova; Frantisek Sehnal; Sarjeet S. Gill ABSTRACT Cul-1 protein is part of the ubiquitin ligase complex that is conserved from yeast to humans. This complex specifically marks cell-cycle regulators for their subsequent destruction. Two null mutations of the cul-1 gene...