...Velislava Tzaneva; Steve F. Perry ABSTRACT Carbon monoxide (CO) is a gaseous neurotransmitter produced from the breakdown of heme via heme oxygenase-1 (HO-1; hypoxia-inducible isoform) and heme oxygenase-2 (HO-2; constitutively expressed isoform). In mammals, CO is involved in modulating cardiac...

...Michael S. Tift; Paul J. Ponganis; Daniel E. Crocker Low concentrations of endogenous carbon monoxide (CO), generated primarily through degradation of heme from heme-proteins, have been shown to maintain physiological function of organs and to exert cytoprotective effects. However, high...

... an affinity 168 times greater for CO than for O 2 . Table 2. Regression analysis of whole-blood oxygen content, rate of oxygen consumption and lactate concentration in developing Fig. 2. Blood oxygen content during exposure to carbon monoxide in Xenopus laevis . The oxygen content of whole...