...Camilla Tornøe; Lindy Holden-Dye; Catherine Garland; Stewart N. Abramson; John T. Fleming; David B. Sattelle ABSTRACT Nematode nicotinic acetylcholine receptors (nAChRs) are molecular targets of several anthelmintic drugs. Studies to date on Caenorhabditis elegans and Ascaris suum have demonstrated...

...R. J. Martin; P. Thorn; K. A. F. Gration; I. D. Harrow ABSTRACT Voltage-activated currents in cell bodies of the somatic muscle cells of Ascaris suum were studied using a two-microelectrode voltage-clamp technique. Cells recorded from had resting membrane potentials around −35 mV and had input...

...L. Colquhoun; L. Holden-Dye; R. J. Walker ABSTRACT Acetylcholine (ACh) elicited depolarization and an increase in input conductance of the somatic muscle cells of the parasitic nematode Ascaris suum . The relative potency of nicotinic and muscarinic agents was studied in this preparation. The order...

...A. J. Pennington; R. J. Martin ABSTRACT Acetylcholine-activated single-channel currents were recorded from cell-attached and inside-out patches of isolated muscle vesicles from Ascaris suum . Acetylcholine (1–10 μmol I −1 ) activated cation-selective channels of two amplitudes: 40–50 pS and 25–35...