... and Forsterygion varium ) . High-resolution respirometry coupled with fluorometric measurements of mitochondrial membrane potential (mtMP) permitted assessment of differences in mitochondrial function and integrity in response to intermittent hypoxia and anoxia. Traditional steady-state measures of respiratory...

...Amanda Bundgaard; Anja V. Gruszczyk; Hiran A. Prag; Catherine Williams; Angela McIntyre; Ilan M. Ruhr; Andrew M. James; Gina L. J. Galli; Michael P. Murphy; Angela Fago ABSTRACT Extremely anoxia-tolerant animals, such as freshwater turtles, survive anoxia and reoxygenation without sustaining tissue...

...Michael Ariel; Shivika Ahuja; Daniel E. Warren ABSTRACT North American pond turtles (Emydidae) are renowned for their ability to survive extreme hypoxia and anoxia, which enables several species to overwinter in ice-locked, anoxic freshwater ponds and bogs for months. Centrally important...

... to low-oxygen stress were studied. The results showed an increase in p-p53 levels during anoxia in both hepatopancreas and tail muscle. Increased transcript levels of ei24 support the activation of p53 under anoxic stress. Cytoplasmic accumulation of Ser15 phosphorylated p53 was observed during anoxia...

... Forskningsråd http://dx.doi.org/10.13039/100008394 0135-00256B Air-breathing fish Anoxia Fuel use Gas exchange Respirometry Teleost Summary: Arapaima gigas maintains aquatic CO 2 excretion in severely hypoxic water but can completely avoid oxygen loss. © 2022. Published...

...Daniel E. Zajic; Jason E. Podrabsky ABSTRACT In most vertebrates, a lack of oxygen quickly leads to irreparable damages to vital organs, such as the brain and heart. However, there are some vertebrates that have evolved mechanisms to survive periods of no oxygen (anoxia). The annual killifish...

..., by microRNAs that can rapidly and reversibly target all biological functions. Herein, we review the involvement of microRNAs in natural models of anoxia and hypoxia tolerance, with a focus on the involvement of oxygen-responsive microRNAs (OxymiRs) in coordinating the metabolic rate depression that allows...

..., but anoxia had no further effect, except in the brain. These results show tissue-dependent sulfide signaling with a potential role in brain metabolic suppression during anoxia in turtles. H 2 S and NO are involved in numerous physiological functions. NO upregulation may contribute to metabolic suppression...

... and reperfusion causes a burst of mitochondrial reactive oxygen species (ROS) in mammals, the question arises as to whether, and if so how, this ROS burst is prevented in the turtle heart. We find that heart mitochondria isolated from turtles acclimated to anoxia produce less ROS than mitochondria from normoxic...

... for surviving anoxia and subsequently reestablishing normal patterns of respiration. Pupae of Manduca sexta were experimentally immersed in water for between 0 and 13 days. All pupae survived up to 5 days of immersion regardless of whether the water was aerated or anoxic. By contrast, fifth-instar larvae...

...Todd E. Gillis; Matthew D. Regan; Georgina K. Cox; Till S. Harter; Colin J. Brauner; Jeff G. Richards; Anthony P. Farrell ABSTRACT Pacific hagfish, Eptatretus stoutii , can recover from 36 h of anoxia at 10°C. Such anoxia tolerance demands the mobilization of anaerobic fuels and the removal...

... The authors declare no competing or financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Summary : Overview of transcriptome regulation by microRNA and its involvement in the coordination of stress survival. Anoxia Environmental stress Freeze-tolerance Hibernation...

...Frank B. Jensen; Marie N. Hansen; Gabriella Montesanti; Tobias Wang Moderate elevations of nitrite and nitric oxide (NO) protect mammalian tissues against ischemia (anoxia)-reperfusion damage by inhibiting mitochondrial electron transport complexes and reducing the formation of reactive oxygen...

...Christopher M. Wilson; Jonathan A. W. Stecyk; Christine S. Couturier; Göran E. Nilsson; Anthony P. Farrell SUMMARY The aneural heart of the Pacific hagfish, Eptatretus stoutii , varies heart rate fourfold during recovery from anoxia. Hyperpolarization-activated cyclic nucleotide-gated (HCN...

...Gina L. J. Galli; Gigi Y. Lau; Jeffrey G. Richards SUMMARY The freshwater turtle Trachemys scripta can survive in the complete absence of O 2 (anoxia) for periods lasting several months. In mammals, anoxia leads to mitochondrial dysfunction, which culminates in cellular necrosis and apoptosis...

...Georgina K. Cox; Erik Sandblom; Anthony P. Farrell SUMMARY In the absence of any previous study of the cardiac status of hagfishes during prolonged anoxia and because of their propensity for oxygen-depleted environments, the present study tested the hypothesis that the Pacific hagfish Eptatretus...

... . Even though adult Drosophila can survive in 0% oxygen (anoxia) environments for hours, air with less than 2% oxygen rapidly induces locomotory failure resulting in an anoxic coma. We use natural genetic variation and an induced mutation in the foraging (for) gene, which encodes a Drosophila PKG...

...-treated embryos had an elevated rotation rate over embryos in APW throughout the long-term exposure to hypoxia. Long-term anoxia also induced a transient increase in rotation rate in embryos exposed to APW or 5-HT. Rotation ceased in embryos exposed to APW by 13 h but persisted in 5-HT-treated embryos...

... activity in invertebrate neurons, we conducted whole-cell recordings from neurons in the central ring ganglia of the anoxia-tolerant pond snail Lymnaea stagnalis during exposure to adenosine and pharmacological compounds known to modulate the type I subclass of adenosine receptors (A 1 R). Action potential...

...) and intermittent anoxia on NO metabolism in eastern oysters, Crassostrea virginica . NOS activity was strongly suppressed by exposure to 50 μg l –1 Cd for 30 days (4.76 vs 1.19 pmol NO min –1 mg –1 protein in control and Cd-exposed oysters, respectively) and further decreased during anoxic exposure in Cd-exposed...