...Marta Grosiak; Paweł Koteja; Catherine Hambly; John R. Speakman; Edyta T. Sadowska ABSTRACT According to the heat dissipation limit (HDL) theory, reproductive performance is limited by the capacity to dissipate excess heat. We tested the novel hypotheses that (1) the age-related decline...

... highlight research that uses NCEs in predator–prey systems to provide novel insights into cognition, adaptation, epigenetic inheritance and aging. I discuss the evolution of instinct, anxiety and other cognitive disorders, the shaping of brain connectomes, stress-induced aging and the development...

... Evolution Neuro-regeneration Aging Consorzio Interuniversitario Biotecnologie What do the experiments that revealed the cellular components of the brain ( Ramón y Cajal, 1894 ; Garcia-Lopez et al., 2010 ), described the mechanisms of nerve impulse transmission ( Castellucci and Kandel...

... lysosomes, a non-canonical lysosome morphology that forms in the gut of hermaphrodites when food is limited or as animals age. We found that constitutive induction of gut tubular lysosomes in males results from self-imposed dietary restriction through DAF-7/TGFβ, which promotes exploratory behavior...

...Marina R. Sartori; Claudia D. C. Navarro; Roger F. Castilho; Anibal E. Vercesi ABSTRACT The interaction between supraphysiological cytosolic Ca 2+ levels and mitochondrial redox imbalance mediates the mitochondrial permeability transition (MPT). The MPT is involved in cell death, diseases and aging...

... seawater lagoons at two facilities (Dolphin Research Center and Dolphin Quest) using the doubly labeled water method. We assessed the relative effects of body mass, age and physical activity on TEE. We also examined whether TEE of bottlenose dolphins, and more generally of marine mammals, differs from...

... for the evaluation of intrinsic resilience during unsteady locomotion in humans and animals, analysing the relationship between the structure of movement variability and resilience. Recovery potential Adaptive capacity Physiological resilience Aging Non-linear dynamics 1/ f structure Humans...

...Jessica M. Judson; Dawn M. Reding; Anne M. Bronikowski ABSTRACT Immunosenescence is a well-known phenomenon in mammal systems, but its relevance in other long-lived vertebrates is less understood. Further, the influence of age and reproductive effort on immune function in long-lived species can...

... observed even among somewhat closely related species; for example, in the laboratory, wild-derived strains of the common house mouse have a maximum observed lifespan of approximately 6 years, while a similarly sized rodent, the naked mole rat, can live for over 30 years. Comparative biology of aging across...

...Ana Gabriela Jimenez; Erin S. O'Connor; Kyle H. Elliott ABSTRACT In birds, many physiological parameters appear to remain constant with increasing age, showing no deterioration until ‘catastrophic’ mortality sets in. Given their high whole-organism metabolic rate and the importance of flight...

... and accelerated aging. We contrasted markers of oxidative damage with antioxidant profiles across age and sex for propulsive (longissismus dorsi) and maneuvering (pectoralis) muscles of Weddell seals to determine whether previously observed morphological senescence is associated with oxidative stress...

...Stephanie P. Kelly; Ken Dawson-Scully ABSTRACT The common fruit fly, Drosophila melanogaster , is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress tolerance and pleiotropy. The foraging ( for ) gene encodes a cGMP-dependent protein...

... the specifics of using VR in spatial navigation research across species, we outline several challenges when investigating age-related deficits in spatial navigation with the help of VR. In addition, we discuss ways to reduce their impact, together with the possibilities VR offers for improving navigational...

...Gaspar Epro; Andreas Mierau; Jonas Doerner; Julian A. Luetkens; Lukas Scheef; Guido M. Kukuk; Henning Boecker; Constantinos N. Maganaris; Gert-Peter Brüggemann; Kiros Karamanidis ABSTRACT The aging musculoskeletal system experiences a general decline in structure and function, characterized...

...Franz Hoelzl; Jessica S. Cornils; Steve Smith; Yoshan Moodley; Thomas Ruf ABSTRACT We studied the impact of hibernation and food supply on relative telomere length (RTL), an indicator for aging and somatic maintenance, in free-living edible dormice. Small hibernators such as dormice have ∼50...

... of both healthy young rats, and old rats where the interaction between contractile and connective tissue properties was assumed to be disrupted. Muscle fiber and aponeurosis stiffness increased with age ( P <0.05) from 19.1±5.0 kPa and 188.5±24.2 MPa, respectively, in young rats to 39.1±4.2 kPa...

... a crucial role in aging and cancer. Reductions in caloric intake have been shown to increase both the life- and health-span in a variety of animal models. Moreover, restriction of glucose has been demonstrated to decrease the incidence of age-related diseases such as cancer and diabetes. A diet rich...

...Lifen Wang; Jason Karpac; Heinrich Jasper; Shireen A. Davies; Julian A. T. Dow; Ken Lukowiak Aging is characterized by a widespread loss of homeostasis in biological systems. An important part of this decline is caused by age-related deregulation of regulatory processes that coordinate cellular...

... that a progressive decline of the efficiency of stress response pathways occurs with aging. In this context, a correct proteostasis is essential for the functionality of the cell, and its dysfunction has been associated with protein aggregation and age-related degenerative diseases. Complex response mechanisms have...

... contributed equally to this work † Author for correspondence ( [email protected] ) 2 8 2012 24 9 2012 © 2013. 2013 insulin insulin-like growth factor mosquito aging signal transduction Malaria is responsible for a quarter of all deaths from infectious diseases...