... mechanisms with putative synergistic roles in the absorption of essential and conditionally essential neutral amino acids. It includes a large paralogous expansion of insect-specific genes, with seven genes from the genome of the malaria mosquito, Anopheles gambiae . One of the An. gambiae NATs, AgNAT8...

..., USA * Author for correspondence (e-mail: [email protected] ) Fig. 8. An H + V-ATPase (V) is electrically coupled by the membrane potential ( V m ) to AgNAT8, a Na + :amino acid transporter (NAT; N) in the apical plasma membrane of posterior midgut (PMG)constituting an NHE VNAT...

... AgNHA1 and H + V-ATPase label the same membranes in An. gambiae larvae. The localization of H + V-ATPase together with(Na + or K + ):amino acid +/– symporter,AgNAT8, on the same apical membrane in posterior midgut cells constitutes the functional equivalent of an NHE that lowers the pH in the posterior...