...,+ -like (rBAT) and a system y + L-like (4F2hc) activity in Xenopus oocytes. Surprisingly, rBAT and 4F2hc do not seem to be pore-forming proteins. This finding supports the hypothesis that rBAT and 4F2hc are subunits or modulators of the corresponding amino acid transport systems. Expression of rBAT...

... ransporters) and 4F2hc , that share amino acid sequence similarity with α -amylases and α -glucosidases. They are type II glycoproteins predicted to span the membrane only once, yet they mediate the Na + -independent transport of cationic and zwitterionic amino acids in Xenopus oocytes. Mutations in the human...