Cover: A swarm of female mosquitoes hover near an infected blood meal opportunity. Unprotected wild-type mosquitoes can become infected and transmit harmful pathogen (blue dots), whereas transgenic mosquitoes (illustrated with a protective DNA barrier) are prevented from supporting a pathogen. A gene drive can be used to spread the protective gene into susceptible wild mosquito populations. In their Review, Raban et al. (jeb208181) discuss different types of gene drives that can be used for population control and how they can be used to solve global health problems related to mosquito-borne diseases. Illustration: Stephanie Gamez.
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Special Issue: Genome Editing for Comparative Physiology
How to turn an organism into a model organism in 10 ‘easy’ steps
Summary: Drawing on our own experience over the past decade with the Aedes aegypti mosquito, we present a series of steps that scientists can take to make non-model species tractable for mechanistic genetic investigation.
How to study enhancers in non-traditional insect models
Summary: We review both experimental and computational approaches useful when studying enhancers in non-traditional model insects. We discuss pros and cons of each approach and key points when applying them to new species.
Evolution, developmental expression and function of odorant receptors in insects
Summary: A review of our understanding of the origins of the olfactory system in insects, the mechanisms of olfactory receptor fate determination, and the extraordinary diversity of behavioral responses to chemical cues.
Molecular evolution of gland cell types and chemical interactions in animals
Summary: Chemical adaptation of animals to new niches has been contingent on the widespread, convergent evolution of exocrine glands. We propose a molecular evolutionary framework for this crucible of metazoan cell type innovation.
Functional genetic analysis in a jawless vertebrate, the sea lamprey: insights into the developmental evolution of early vertebrates
Summary: This Review summarizes progress in the application of functional genomic tools in lamprey embryos to provide insight into the evolution of developmental mechanisms in vertebrates.
Studying convergent evolution to relate genotype to behavioral phenotype
Summary: Using functional genomics tools to study the convergent evolution of behavior allows a better understanding of genotype–phenotype relationships and how behavior evolves and diversifies.
Utilizing the blind cavefish Astyanax mexicanus to understand the genetic basis of behavioral evolution
Summary:Astyanax mexicanus is an excellent model system for examining the genetic basis of complex traits. This Review discusses how gene editing tools can be used to further understand how behaviors evolve.
Diversity in reproductive seasonality in the three-spined stickleback, Gasterosteus aculeatus
Summary: Summary of interpopulation variation in seasonal reproduction of the three-spined stickleback and recent progress in our understanding of the physiological basis of seasonal reproduction in this species.
The turquoise killifish: a genetically tractable model for the study of aging
Summary: Turquoise killifish constitute a new powerful vertebrate model system in the biology of aging, with their short natural lifespan and a broad spectrum of aging phenotypes.
Gene manipulation to test links between genome, brain and behavior in developing songbirds: a test case
Summary: Songbirds such as the zebra finch are powerful models in which to investigate neural and genomic mechanisms of complex learned behavior. Genomic manipulation is a powerful tool to advance these inquiries.
Recent advances in functional genomics for parasitic nematodes of mammals
Summary: Parasitic nematodes cause devastating diseases affecting billions of people. We describe new technical advances that are providing long-overdue insights into the biology of these pathogens.
Progress towards engineering gene drives for population control
Summary: Gene drives are an important emerging technology. This review discusses the current state of gene drive technologies for vector-borne disease control and their performance and safety features.
Genome editing approaches to augment livestock breeding programs
Summary: Genome editing could complement traditional livestock genetic improvement programs by fixing favorable alleles, introducing useful genetic variation and accelerating the rate of genetic gain.
The coding loci of evolution and domestication: current knowledge and implications for bio-inspired genome editing
Summary: A review of >1200 identified coding mutations underlying domestication and natural evolution uncovers knowledge biases, shows that null mutations are prevalent and provides insights for successful genome editing.
Bringing immersive science to undergraduate laboratory courses using CRISPR gene knockouts in frogs and butterflies
Summary: Incorporating CRISPR genome editing of butterflies and frogs into undergraduate laboratory courses allows for inquiry-based learning and genuine scientific experiences.
New funding schemes for junior faculty staff
In celebration of our 100th anniversary, JEB has launched two new grants to support junior faculty staff working in animal comparative physiology and biomechanics who are within five years of setting up their first lab/research group. Check out our ECR Visiting Fellowships and Research Partnership Kickstart Travel Grants. First deadline for applications is 15 July 2023.
JEB@100: an interview with Monitoring Editor Sanjay Sane
Sanjay Sane tells us about his first experience of publishing with the journal and why he thinks JEB is going to play a key role in our understanding of the current climate crisis and its implications for biodiversity.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Experimental Biology a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Celebrating 100 years of discovery
This Special Issue focuses on broad biological questions addressed through the lens of comparative biomechanics. Crosscutting through time, this series of Reviews, Commentaries and Research Articles addresses questions from the vantage points of the history of the field, today’s research, and the future of comparative biomechanics. Read the Editorial by Sheila Patek, Monica Daley and Sanjay Sane.
Centenary Review - Adaptive echolocation behavior
Cynthia F. Moss and colleagues Review the behaviours used by echolocating mammals to track and intercept moving prey, interrogate dynamic sonar scenes, and exploit visual and passive acoustic stimuli.
Crucial DNA at crux of insect wing size evolution
Keity Farfán-Pira and colleagues have revealed that a tiny region of regulatory DNA in the vestigial gene governs whether insect wings are large or small and has played a key role in the evolution of insect wing size.