The midgut of the American silkworm transports potassium actively from blood side to lumen. The active K transport was measured by short-circuiting the gut. The K transport is inhibited by Tl in the lumen solution. A Lineweaver-burk plot showed that the inhibition with Tl is competitive with the active K transport. The Km was found to be 5.7 +/− 0.7 and Ki = 0.1. It was conclude that Tl acts on the K pump which is located close to the lumen of the gut. When Tl was applied to the blood-side, only about half inhibition is found, yet, paradoxically, Tl concentration in the gut tissue was ten times as high as when Tl was applied to the lumen side.
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JOURNAL ARTICLE| 01 February 1982
Inhibition of active K transport in the isolated midgut of Hyalophora cecropia by Tl+
Online Issn: 1477-9145
Print Issn: 0022-0949
© 1982 by Company of Biologists
J Exp Biol (1982) 96 (1): 307–313.
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K. Zerahn; Inhibition of active K transport in the isolated midgut of Hyalophora cecropia by Tl+. J Exp Biol 1 February 1982; 96 (1): 307–313. doi: https://doi.org/10.1242/jeb.96.1.307
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