Long-term facilitation (LTF) and short-term facilitation (STF) at excitatory neuromuscular junctions were studied under conditions of varying [K+]0 and with the addition of strophanthidin.
The magnitude of LTF varied inversely with [K+]0, while STF was unaffected.
Strophanthidin concentrations greater than 10−5 M greatly increased LTF, but not STF.
Both LTF and STF were unaffected by large decreases in excitatory junctional potential amplitude produced by the addition of GABA or Mn+2.
The results support the hypothesis that LTF is a consequence of Na+ accumulation in presynaptic terminals and behaves independently of STF.
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JOURNAL ARTICLE| 01 June 1980
Neuromuscular Facilitation in Crayfish: Dependence on Potassium and Strophanthidin
C. LEO ORTIZ,
C. LEO ORTIZ
1 Biology Board of Studies, University of California Santa Cruz, California 95064
R. K. ORKAND
2 Department of Physiology and Pharmacology, School of Dental Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104
Revision Received: 20 Sep 1979
Online Issn: 1477-9145
Print Issn: 0022-0949
© 1980 by Company of Biologists
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C. LEO ORTIZ, R. K. ORKAND; Neuromuscular Facilitation in Crayfish: Dependence on Potassium and Strophanthidin. J Exp Biol 1 June 1980; 86 (1): 39–47. doi: https://doi.org/10.1242/jeb.86.1.39
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