The monosynaptic connexion between the trochanteral hairplate afferents and the motoneurone D8 was investigated pharmacologically.
Electrical stimulation of the hairplate produced a 1:1 reflex activation of D8 which was blocked by saline containing 50 mM-Mg2+.
Changes in the hairplate-to-D8 reflex and in the tonic activity of D8 were monitored during perfusion of drugs known to affect cholinergic transmission.
The reflex response was blocked by cholinergic antagonists (atropine, d-tubocurarine, α-bungarotoxin, hexamethonium, decamethonium and TMA); and by an inhibitor of ACh synthesis (hemicholinium-3); it was blocked and desensitized by agonists (carbachol and nicotine) and depolarized and blocked by an AChE inhibitor (eserine).
These results are consistent with the hypothesis that ACh is a sensory transmitter in the insect CNS.
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JOURNAL ARTICLE| 01 June 1980
Pharmacological Analysis of a Monosynaptic Reflex in the Cockroach, Periplaneta Americana
CATHERINE E. CARR,
CATHERINE E. CARR
1 Department of Neuroscience, University of California San Diego, M-008, La Folla, California 92037
CHARLES R. FOURTNER
2 Department of Biological Sciences, State University of New York Buffalo, Buffalo, New York 14260
Revision Received: 30 Aug 1979
Online Issn: 1477-9145
Print Issn: 0022-0949
© 1980 by Company of Biologists
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CATHERINE E. CARR, CHARLES R. FOURTNER; Pharmacological Analysis of a Monosynaptic Reflex in the Cockroach, Periplaneta Americana. J Exp Biol 1 June 1980; 86 (1): 259–273. doi: https://doi.org/10.1242/jeb.86.1.259
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