1. Methods for presenting dose-response data for the ganglionic actions of cholinergic agonists (e.g. carbamylcholine) are compared, using the mannitol-gap technique for electrophysiological recording of synaptic events at the cercal nerve, giant fibre synapse of the sixth abdominal ganglion of the cockroach Periplaneta americana. 2. At concentrations around 10(−5)M, carbamylcholine has no effect on ganglionic polarization but potentiates the monosynaptic EPSP. At 10(−4)M and higher concentrations, ganglionic depolarization is accompanied by a reduction of EPSP. 3. Pretreatment with eserine (10(−6) M) considerably shifts the dose-response curve for acetylcholine so that synaptic transmission is consistently sensitive to 10(−6) M acetylcholine.
The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine
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D. B. Sattelle, A. S. McClay, R. J. Dowson, J. J. Callec; The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine. J Exp Biol 1 February 1976; 64 (1): 13–23. doi: https://doi.org/10.1242/jeb.64.1.13
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