Injections of 5-hydroxytryptamine (5-HT, serotonin) are found to cause plasticization of the abdominal cuticle of Rhodnius larvae. This plasticization is a direct action of 5-HT on some element in the body wall; the central nervous system is not required. It is probable that 5-HT acts directly at a receptor on the epidermal cells. The relationship between structure and plasticizing activity for a number of 5-HT analogues has been investigated. The receptor resembles other ‘classical’ 5-HT receptors in its requirements, but is unlike the 5-HT/diuretic hormone receptor of Rhodnius Malpighian tubules.
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JOURNAL ARTICLE| 01 December 1974
Pharmacological Induction of Plasticization in the Abdominal Cuticle of Rhodnius
STUART E. REYNOLDS
Department of Zoology, Downing Street, Cambridge; Department of Zoology, University of Bristol, Woodland Road, Bristol, BS8 1UG
Received: 02 Jul 1974
Online Issn: 1477-9145
Print Issn: 0022-0949
Copyright © 1974 The Company of Biologists Ltd.
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STUART E. REYNOLDS; Pharmacological Induction of Plasticization in the Abdominal Cuticle of Rhodnius. J Exp Biol 1 December 1974; 61 (3): 705–718. doi: https://doi.org/10.1242/jeb.61.3.705
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