Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l-1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ from internal stores using either inositol 1,4,5-trisphosphate or ryanodine receptors. Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca2+ signals that regulate cellular activity.
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REVIEW| 01 January 1997
Elementary and global aspects of calcium signalling.
M J Berridge
Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK. email@example.com
Online Issn: 1477-9145
Print Issn: 0022-0949
J Exp Biol (1997) 200 (2): 315–319.
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M J Berridge; Elementary and global aspects of calcium signalling.. J Exp Biol 1 January 1997; 200 (2): 315–319. doi: https://doi.org/10.1242/jeb.200.2.315
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