The role of an increase in oxidative potential of skeletal muscle in the enhanced work capacity and greater use of fat as a fuel after endurance training is discussed. Evidence is presented to illustrate that this adaptive response is probably expressed at the cellular level by a more rapid translocation into the mitochondria of the ADP generated during contractile activity. The consequence of this is a tighter control over the glycolytic process thereby creating more favourable conditions for the entry of acetyl units derived from beta-oxidation of fatty acids into the citric acid cycle.

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