In the course of experiments undertaken in this department to throw further light on the co-ordination of pigmentary changes in Amphibia, various indications have arisen to suggest that the pressor and melanophore components of extracts of the pituitary gland are not one and the same substance. The separate identity of the pressor and oxytocic components first indicated by Dale and Dudley (1921) has now been established beyond reasonable doubt by the work of Schlapp (1925) and of Draper (1926) who have availed themselves of a method of pressor assay devised by Hogben, Schlapp and Macdonald (1924) to permit comparison with a precision of the same order as that of Dale’s oxytocic standardisation. By the methods of separation used by Schlapp and a third method used by Dreyer and Clark (1924), it is not possible to state with certainty that the melanophore and pressor activities are referable to separate...

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