In a previous communication of this series an account was given of the relation of Rations to contractile rhythm of certain invertebrate preparations (Hogben, 1925). The data therein recorded emphasise the conclusions derived from other researches such as those of Mines and Clark (1921) who have shown that whereas, when dealing with the same species and the same type of contractile tissue, entirely consistent phenomena are encountered, effects of a totally different character are met with in studying the relation of a particular ion to analogous muscle preparations in other species. The possibility of harmonising these discrepancies was indicated in a critical summary (Hogben, op. cit.) in which attention was directed to the imperative necessity of a comprehensive study of the relation of electrolytes to the physical properties of muscle. The present research was undertaken as a contribution with that end in view; and was suggested...

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