1. Sodium and lithium are actively transported by the isolated midgut of Hyalophora cecropia.

  2. The short-circuit current in 32 mM sodium solution is about half of that in 32 mm potassium solution.

  3. The sodium flux measured with 22Na from blood-side to lumen accounts for all of the short-circuit current and is 19 times the flux from lumen to blood-side.

  4. In a solution containing 16 mm potassium and 16 mm sodium there is no transport of sodium, although a large current remains.

  5. The sodium transport mechanism is not sensitive to ouabain.

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