Since the appearance of the works of Weiske, Voit, Forster, and others of later years, numerous attempts have been made to determine the various factors involved in calcium metabolism. Patterson carried out feeding experiments on rabbits and on himself and found that even a dietary deficient in calcium induced no loss of calcium in the blood. Moreover, with a fixed diet the urinary calcium varied but slightly, the variations being parallel with total amounts of urine excreted. One of his conclusions was that the greater the volume of urine excreted the greater was the mass of salts eliminated.

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