‘Wild’ house mice (Mus musculus L.) breed in cold stores kept at about–10° C (Laurie, 1946), and laboratory mice of the same species can be bred at an environmental temperature of–3° C., given nesting material (Barnett & Manly, 1954; Barnett, 1956). The response of mice to low temperatures varies with different inbred strains. The differences are reflected in mortality (especially of young), growth, numbers of young born and weaned, and in internal, especially endocrine, changes. All these, and other aspects of the maintenance of the lives of mice at low temperatures, are to be discussed in future communications.

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