Previous studies from this laboratory have indicated that the distribution of lipids in the mammalian central nervous system is very similar for a number of different species (Johnson, McNabb & Rossiter, 1948 a). The same is true for the lipids of peripheral nerve (Johnson et al. 1948 b). Johnson et al. (1949 a, b) concluded that free cholesterol, cerebroside and sphingomyelin are the principal lipids of the myelin sheath of a mammalian nerve fibre, although the recent work of Brante (1949) suggests that one of the components of brain kephalin, phosphatidyl serine, may also be present in considerable quantities in the myelin sheath. These lipids have been called the myelin lipids.

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