Homer William Smith (1895–1962) was best known for his work as a renal physiologist. His extensive research on the mammalian kidney greatly enhanced our understanding of the functional properties of the glomeruli, tubules and renal vascular bed, and his examination and comprehension of functional alterations in renal disease garnered him a great deal of respect from clinical physicians and physiologists alike (Pitts, 1967). While the majority of his time was focused on clinical studies in mammals, Smith spent his summers at the Mount Desert Island Biological Laboratory (MDIBL) in Salisbury Cove (ME, USA) ‘dabbling’ in comparative physiology (Evans, 2008). Dabbling should be a term used lightly as Smith's early experiments in comparative physiology built the foundation for our current knowledge of nitrogen excretion in fish. In his seminal 1929 paper in the Journal of Biological Chemistry, Smith became the first researcher to report that the...

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