Diurnal rhythms in plants and animals have been observed for centuries, but their endogenous and circadian nature were not acknowledged until the 1960s (Menaker, 1969). Research during that decade provided ample evidence for an internal `clock' generating daily rhythms in behavior through biochemistry; however, the nature and anatomical location of this clock were a mystery. Insects helped to unveil this paradox, providing critical early insights into both the genetic and the physiological bases of the clock. The discovery of the first circadian clock gene period in Drosophila melanogaster was a milestone for chronogenetics (Konopka and Benzer, 1971). The overt behavior used to identify arrhythmic period mutants in flies was the rhythm of emergence of the adult from its pupal cuticle. This event, termed eclosion, is `gated' by the circadian clock, which means that it can only occur in a restricted portion of a day/night cycle. This...

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