It has been shown that the removal of the pituitary body in mammals is generally fatal. Adler, whose work was extended by Allen, Smith, Atwell, and Hogben, has shown that such fatal results do not attend the removal of the amphibian pituitary body. The former investigators were able to destroy the hypophysial rudiment in the frog embryo, and prove that failure to metamorphose is the inevitable consequence of this operation. This work has been strengthened by the observations of Allen and Swingle on the acceleration of the metamorphosis in frog tadpoles by the implantation of the pituitary gland, and they concluded that the anterior portion (pars anterior) was responsible for this curtailment of the larval period. However, Gudernatsch and others found that pituitary feeding does not stimulate metamorphosis in Anura, and Huxley and Hogben obtained similar results with axolotls after feeding several months with anterior lobe. Later, Hogben found that...

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