ABSTRACT
The fungal vacuole is a prominent organelle that functions as a storage site for amino acids, Ca2+, storage carbohydrates, inorganic phosphate and numerous hydrolases (Fig. 1) (Klionsky et al. 1990). A hallmark of fungal vacuoles is that they are acidic compartments involved in the turnover of cellular macromolecules. In the yeast Saccharomyces cerevisiae, the hydrolase activities in the vacuole are required for diploid cells to progress normally through sporulation and meiosis. The goal of this chapter is to present an overview of what is known about the enzyme complex responsible for acidifying the fungal vacuole and to summarize the current view of the function of acidification of the vacuolar network.
© 1992 by Company of Biologists
1992
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