The isolated gut of Aplysia californica (seahare), bathed in a substrate-and Na+-free seawater bathing medium, generates a serosa-negative transepithelial potential difference and the concomitant short-circuit current (Isc), which is inhibitable by acetazolamide, was shown to be identical to a net active absorptive flux of Cl− (Gerencser, 1984). Additionally, Gerencser and Lee (1983, 1985) demonstrated the existence of a Cl−-stimulated ATPase activity in Aplysia gut absorptive cell basolateral membranes (BLM), which was also strongly inhibited by acetazolamide. Furthermore, Gerencser (1986) demonstrated acetazolamide inhibition of ATP-dependent Cl− uptake and ATP-dependent vesicular membrane potential change in Aplysia inside-out absorptive cell BLM vesicles. A recent study demonstrating reconstitution of Cl−-stimulated ATPase activity into liposomes with subsequent Cl” accumulation in the presence of ATP provided strong evidence for the existence of a primary active transport mechanism for Cl− (...
Announcing the 2024 JEB Outstanding Paper Prize shortlist and winner
Every year JEB celebrates early-career researchers through the Outstanding Paper Prize. We recognise the shortlisted ECRS that contributed to 11 remarkable studies published in 2024 and congratulate the winner, Elise Laetz, from University of Groningen. See how else JEB supports and promotes ECRs.
Inside the Intergovernmental Panel on Climate Change with Hans-Otto Pörtner
During the past two decades, Hans-Otto Pörtner has steered climate change policy as a co-Chair of IPCC Working Group II. He tells us about the experience in this Perspective.
Photosynthesis turns symbiotic sea anemone's tentacles toward sun
Snakelocks sea anemones point their tentacles, packed with symbiotic algae, toward the sun so their lodgers can photosynthesize, and now Vengamanaidu Modepalli & colleagues have discovered that photosynthesis by the algae guides their host's tentacles towards the sun.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about JEB’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Disease Models & Mechanisms and Biology Open.
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