ABSTRACT
In searching for cellular mechanisms by which nervous systems store learned information, it is helpful to differentiate properties which are genetically programmed from those which are conferred by the interaction of an organism with its environment. With mechanisms of learning, as with those underlying developmental transformations, a chronology must be reconstructed - a sequence of processes which arise as a consequence of preceding conditions. To construct such a chronology, the cellular site at which learned information is stored must be accessible to analysis so that we may watch it during sequential transformations, and so that we can measure with appropriate morphological, biophysical and biochemical techniques the nature and magnitude of the critical changes.