A number of tests were carried out to find the duration of the changes induced in the mouse ovary by prolan, and whether they were completely evanescent or productive of more or less permanent alterations. The question is of some interest in view of Mandelstamm and Tschaikowsky’s results (1931) in the production of temporary sterility in mice with prolan, and their experiment was repeated in a modified form with a few animals. Katzman has also reported that the B hormone from pregnancy urine produces profound ovarian luteinisation and complete inhibition of oestrus in rats, but that the impairment of the reproductive mechanism is not permanent.

Copyright © 1934 The Company of Biologists Ltd.
1934
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