...Francesca Patella; Daniel F. Cutler ABSTRACT The haemostatic protein von Willebrand factor (VWF) exists in plasma and subendothelial pools. The plasma pools are secreted from endothelial storage granules, Weibel–Palade bodies (WPBs), by basal secretion with a contribution from agonist-stimulated...

... by von Willebrand factor, their most abundant protein, which controls both shape and size of WPBs. WPB are generated in a range of sizes, with the largest granules over ten times the size of the smallest. In this Cell Science at a Glance and the accompanying poster, we discuss the emerging mechanisms...

..., inflammation and angiogenesis, including the pro-thrombotic glycoprotein von Willebrand factor (VWF). Although many protein components required for WPB formation and function have been identified, the role of lipids is almost unknown. We examined two key phosphatidylinositol kinases that control...

... ). Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor . Mol. Biol. Cell 13 , 1582 - 1593 . Cowan A. E. , Olivastro E. M. , Koppel D. E. , Loshon C. A. , Setlow B. , Setlow P...

... vary between endothelial tissues, reflecting their differing physiological circumstances. The particular functional demands of the highly multimerised haemostatic protein von Willebrand Factor (VWF), which is stored in WPBs as tubules until release, are responsible for the cigar shape of these granules...

... of internal striations running parallel to their long axis that are revealed as tubules in transverse section ( Weibel and Palade, 1964 ). These tubules are von Willebrand Factor (VWF), a key haemostatic mediator, which is stored within the organelle ( Wagner et al., 1982 ). We have demonstrated...