... pharmacological- or siRNA-mediated inhibition of FAK, but not PYK2, reduced the expression of LIF and IL-6 in C6 and endothelial cells and after traumatic cell injury. Dominant-negative FAK (Y397F) reduced the amount of injury-induced LIF and IL-6. Pharmacological inhibition or knockdown of uPAR (also known...

...Daniela Alfano; Pia Ragno; M. Patrizia Stoppelli; Anne J. Ridley Urokinase-type plasminogen activator (uPA) and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously...

...Silvia D'Alessio; Laura Gerasi; Francesco Blasi The urokinase receptor (uPAR) is involved in a series of pathological processes, from inflammation to cancer. We have analyzed in detail the role of uPAR and the mechanisms involved in keratinocyte behavior during wound healing by exploiting uPAR...

...Elizabeth Monaghan-Benson; Cynthia Corley Mastick; Paula J. McKeown-Longo The relationship between the plasminogen activator system and integrin function is well documented but incompletely understood. The mechanism of uPAR-mediated signaling across the membrane and the molecular basis of uPAR...

... of the transcription factor HOXA3 in wound repair and angiogenesis. Here we show that HOXA3 increases endothelial cell migration, induces angiogenesis in vivo, and leads to increased expression of the matrix metalloproteinase-14 ( MMP-14 ) and urokinase-type plasminogen activator receptor ( uPAR ) genes in endothelial...

... -integrins regulate expression of the urokinase-type plasminogen activator receptor(uPAR) through outside-in signalling involving the cytoplasmic domain. Here we show that overexpression of the integrin-binding proteinβ 3 -endonexin decreased uPAR promoter (-398 base-pair fragment)activity...

...Zhong Ma; Donna J. Webb; Minji Jo; Steven L. Gonias Urokinase-type plasminogen activator (uPA) binds to the uPA receptor (uPAR) and activates the Ras-extracellular signal-regulated kinase (ERK) signaling pathway in many different cell types. In this study, we demonstrated that endogenously produced...

...Lothar Goretzki; Barbara M. Mueller ABSTRACT Internalization of the urokinase-type plasminogen activator (uPA) requires two receptors, the uPA receptor (uPAR) and the low density lipoprotein receptor-related protein (LRP)/α 2 -macroglobulin (α 2 M) receptor. Here, we address whether protein kinases...