..., and participates in inflammatory transendothelial migration (TEM). Tumour cells also express CD99, and we have analysed its role in tumour progression and cancer cell TEM. Tumour cell CD99 was required for adhesion to ECs but inhibited invasion of the endothelial barrier and migratory activity. Furthermore, CD99...

...Max L. B. Grönloh; Janine J. G. Arts; Jaap D. van Buul ABSTRACT During inflammation, leukocytes circulating in the blood stream exit the vasculature in a process called leukocyte transendothelial migration (TEM). The current paradigm of this process comprises several well-established steps...

... of the Mena11a isoform, expressed in primary tumor cells, are largely unknown. Here, we provide evidence that elevated Mena INV increases coordinated streaming motility, and enhances transendothelial migration and intravasation of tumor cells. We demonstrate that promotion of these early stages of metastasis...

.... * Present address: CellGenix, D-79110 Freiburg, Germany 14 11 1996 06 01 1997 © 1997 by Company of Biologists 1997 Inflammation Transendothelial migration Cell adhesion Fig. 1. MAb 11D4.1 immunoprecipitates VE-cadherin. Mouse endothelioma cell line eEnd.2...

... by interaction with HEC. Together these results suggest that transendothelial migration is regulated by increases in the affinity of 4 1 integrin on lymphocytes following contact with HEC. * Author for correspondence † Present address: Laboratory of Cellular Immunology, National Institute for Medical...