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Keywords: transcription
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Journal Articles
J Cell Sci jcs.261790.
Published: 6 June 2024
...Bina Prajapati; Maria Sokolova; Ekaterina Sidorenko; Mikael Kyriacou; Salla Kyheröinen; Anniina Vihervaara; Maria K. Vartiainen Myocardin-related transcription factors (MRTFs) are coactivators of serum response factor (SRF), and thereby regulate cytoskeletal gene expression in response to actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (6): jcs261630.
Published: 2 April 2024
... clustering of the AR for the formation of transcriptionally active condensate-like droplets via the assembly of highly dynamic actin polymers. Together, these examples highlight that dynamic nuclear actin polymerization regulates gene transcription in response to different signaling cues by modulating...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2023) 136 (10): jcs260631.
Published: 18 May 2023
... fine tune the induction of autophagy without complete abrogation. In this Review, we summarize the recent discoveries on the mechanism of regulation of ATG (autophagy related) gene expression at the level of transcription, post transcription and translation. Furthermore, we briefly discuss the role...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (2): jcs258818.
Published: 26 January 2022
... to wild-type data, uncoupling Hi-C-measured long-range DNA contacts from transcriptional repression of the X chromosomes. Taken together, our results indicate that DPY-21 has a non-catalytic role in regulating the dynamics of condensin DC binding, which is important for transcription repression. Next...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs259097.
Published: 12 January 2022
... signaling results in TAZ Ser89 phosphorylation and increased retention in the cytoplasm. Based on the repressive function of TAZ at the Ckm gene that we have documented here, we propose that TAZ represses myogenic transcription complexes under proliferative conditions, and activation of Hippo signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (5): jcs252544.
Published: 9 November 2020
... early in infection remained unexplained. We thus assessed the amount of transcriptionally active nuclear vDNA. Cellular gene loci active in transcription have been visualized using RNA FISH targeting intron sequences ( Levesque and Raj, 2013 ; Shah et al., 2018 ), or by monitoring transcriptional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
... ). This, together with its localisation on promyelocytic leukaemia protein (PML) nuclear bodies ( Majewski et al., 2018 ), which consist of chromatin and transcription activators, suggests that MVI is present in a number of transcriptionally active areas in the nucleus. MVI also mediates the transition from...
Journal Articles
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
.... However, the molecular mechanisms that regulate nuclear structure–function relationships during heat shock remain unclear. Here, we show that lamin A and C (hereafter lamin A/C; both lamin A and C are encoded by LMNA ) are required for heat-shock-mediated transcriptional induction of the Hsp70 gene locus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 1 November 2019
... of genes, whose functions include regulation of the cell cycle, transcription and metabolism ( Mahat et al., 2016 ; Vihervaara et al., 2017 ). In vertebrates, the HSR is transcriptionally regulated by a family of heat-shock factors (HSFs) comprising several members, namely, HSF1, HSF2, HSF3, HSF4...
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
... and in cells. Transient interactions detected through BioID link actin to several steps of transcription as well as to RNA processing. Alterations in nuclear actin levels disturb alternative splicing in minigene assays, likely by affecting the transcription elongation rate. This interactome analysis thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs222729.
Published: 7 February 2019
... associates differently with RNA polymerase II; a gene reporter assay revealed that HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription. Thus, these studies provide the basic clues pertaining to the molecular mechanism by which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs220491.
Published: 7 February 2019
... domains or TADs, antagonize the formation of epigenetically defined but untethered DNA volumes, termed compartments. While condensin complexes formed through cis -interactions must maintain chromatin compaction throughout mitosis, cohesins remain highly dynamic during interphase to allow for transcription...
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (20): jcs210971.
Published: 22 October 2018
...Dennis Klug; Jessica Kehrer; Friedrich Frischknecht; Mirko Singer ABSTRACT Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213967.
Published: 5 June 2018
...-knockdown cells. RANKL-dependent adseverin expression in bone marrow cells was increased by both IL1β (5.4-fold) and TNFα (3.3-fold). Luciferase assays demonstrated that this expression involved transcriptional regulation of the adseverin promoter. Activation of the promoter was restricted to a 1118 bp...