1-20 of 91
Keywords: transcription
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (15): jcs259051.
Published: 05 August 2021
... in post-transcriptional control of mRNA levels supports our initial hypothesis that the decreased level of nascent mRNA in an H3K56A mutant might be protected from degradation and thus post-transcriptionally buffered to ensure homeostasis of gene expression and cell survival. Several mRNA targets...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 04 June 2021
... including protein biosynthesis and transcription, and dedicated follow-up experiments highlight the importance of accurate transcriptional and translational control for mitigating protein aggregation and toxicity during arsenite stress. Some of the hits are associated with pathological conditions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs252544.
Published: 09 November 2020
... of adenovirus (AdV) infection. AdV delivers, transcribes and replicates a linear double-stranded DNA genome in the nucleus. We measured the abundance of viral transcripts using single-molecule RNA fluorescence in situ hybridization (FISH) and the incoming 5-ethynyl-2′-deoxycytidine (EdC)-tagged viral genomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 04 June 2020
... that MVI is present in a number of transcriptionally active areas in the nucleus. Furthermore, given the interaction of MVI with both the estrogen receptor ( Fili et al., 2017 ) and the androgen receptor ( Loikkanen et al., 2009 ), we speculate that MVI is required for the transcription of specific...
Journal Articles
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
.... However, the molecular mechanisms that regulate nuclear structure–function relationships during heat shock remain unclear. Here, we show that lamin A and C (hereafter lamin A/C; both lamin A and C are encoded by LMNA ) are required for heat-shock-mediated transcriptional induction of the Hsp70 gene locus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 01 November 2019
... regulation of the cell cycle, transcription and metabolism ( Mahat et al., 2016 ; Vihervaara et al., 2017 ). In vertebrates, the HSR is transcriptionally regulated by a family of heat-shock factors (HSFs) comprising several members, namely, HSF1, HSF2, HSF3, HSF4, HSF5, HSFXs and HSFYs, whereas...
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
... and in cells. Transient interactions detected through BioID link actin to several steps of transcription as well as to RNA processing. Alterations in nuclear actin levels disturb alternative splicing in minigene assays, likely by affecting the transcription elongation rate. This interactome analysis thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs222729.
Published: 07 February 2019
... proteins at the transcriptionally active chromatin region, and HP1b may be recruited through forming heterodimers with HP1c at the region. Taken together, these data indicate that HP1b and HP1c may counteract HP1a function both in heterochromatin formation and in the active transcriptional regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs220491.
Published: 07 February 2019
... ). It is tempting to speculate that the TAD base insulates looped and non-looped DNA from transcription and chromatin-remodeling factors that migrate along DNA. In terms of genome biology, the term compartment is narrowly defined: compartments are untethered, but self-interacting domains of transcriptionally active...
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... of transcription. We first analyzed Arc mRNA and pre-mRNA levels in Upf1 knockdown and KO cells by qRT-PCR and found that these did not differ significantly ( Figs 1 C,D and 2 B–D), strongly suggesting that Arc mRNA is transcriptionally modulated. The Arc promoter has been well characterized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs210971.
Published: 22 October 2018
...Dennis Klug; Jessica Kehrer; Friedrich Frischknecht; Mirko Singer ABSTRACT Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213967.
Published: 05 June 2018
...-knockdown cells. RANKL-dependent adseverin expression in bone marrow cells was increased by both IL1β (5.4-fold) and TNFα (3.3-fold). Luciferase assays demonstrated that this expression involved transcriptional regulation of the adseverin promoter. Activation of the promoter was restricted to a 1118 bp...
Journal Articles
J Cell Sci (2018) 131 (9): jcs211631.
Published: 08 May 2018
... previously, the holo-TFIIH complex (composed of the core and CAK subcomplexes) is required for transcription by RNAPII. Considering that ZGA occurs during the pre-MBT, we expected to observe core and CAK colocalization in transcriptionally active nuclei in pre-MBT embryos (i.e. at the interphase of NC8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2049–2055.
Published: 15 June 2017
... signalling. Sck2 had the greatest effect on cell growth, and we also show that it significantly increases the cellular transcription rate. These findings indicate, for the first time, that global transcriptional control mediated through S6 kinase signalling is central to cellular growth control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3412–3425.
Published: 15 September 2016
... and activity of the SRF cofactor MAL . Science   316 , 1749 - 1752 . 10.1126/science.1141084 Wang , I.-F. , Chang , H.-Y. and James Shen , C.-K. ( 2006 ). Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition . Exp. Cell Res...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (16): 3059–3066.
Published: 15 August 2016
... been shown to be involved in the vesicular trafficking of autophagy and to be transcriptionally regulated by the JNK–Jun pathway following amino-acid starvation ( Moreau et al., 2015 ) (see poster). Since ANXA2 overexpression itself induces autophagy, the JNK–Jun–ANXA2 transcriptional program appears...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2448–2461.
Published: 15 June 2016
.... Milburn; Jenny Dunn; Marco G. Casarotto; Stephen J. Turner; Nabila Seddiki; Anthony D. Kelleher; Sudha Rao ABSTRACT Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 145–154.
Published: 01 January 2016
... developmental event whose molecular regulation remains incompletely defined. We now demonstrate the role of Rgs18, a GTPase-activating protein and transcriptional target of the repressor Gfi1b, in regulating these processes in mouse and human cells. Gfi1b stringently represses Rgs18 expression in erythroid...
Includes: Supplementary data