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Keywords: transcription
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259972.
Published: 26 April 2022
... transcriptional partners. However, the network of factors that controls SMAD2 chromatin binding and shapes its transcriptional programme over time is poorly characterised. Here, we combine ATAC-seq with computational footprinting to identify temporal changes in chromatin accessibility and transcription factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs258818.
Published: 26 January 2022
... to wild-type data, uncoupling Hi-C-measured long-range DNA contacts from transcriptional repression of the X chromosomes. Taken together, our results indicate that DPY-21 has a non-catalytic role in regulating the dynamics of condensin DC binding, which is important for transcription repression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs259097.
Published: 12 January 2022
.... References Alarcon , C. , Zaromytidou , A. I. , Xi , Q. , Gao , S. , Yu , J. , Fujisawa , S. , Barlas , A. , Miller , A. N. , Manova-Todorova , K. , Macias , M. J. et al. ( 2009 ). Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs259051.
Published: 5 August 2021
...David Z. Kochan; Julia S. P. Mawer; Jennifer Massen; Kiril Tishinov; Swati Parekh; Martin Graef; Anne Spang; Peter Tessarz ABSTRACT Gene expression involves regulation of chromatin structure and transcription, as well as processing of the transcribed mRNA. While there are feedback mechanisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 4 June 2021
... including protein biosynthesis and transcription, and dedicated follow-up experiments highlight the importance of accurate transcriptional and translational control for mitigating protein aggregation and toxicity during arsenite stress. Some of the hits are associated with pathological conditions...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (5): jcs252544.
Published: 9 November 2020
... early in infection remained unexplained. We thus assessed the amount of transcriptionally active nuclear vDNA. Cellular gene loci active in transcription have been visualized using RNA FISH targeting intron sequences ( Levesque and Raj, 2013 ; Shah et al., 2018 ), or by monitoring transcriptional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
...-mRNA processing ( Majewski et al., 2018 ). This, together with its localisation on promyelocytic leukaemia protein (PML) nuclear bodies ( Majewski et al., 2018 ), which consist of chromatin and transcription activators, suggests that MVI is present in a number of transcriptionally active areas...
Journal Articles
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
.... However, the molecular mechanisms that regulate nuclear structure–function relationships during heat shock remain unclear. Here, we show that lamin A and C (hereafter lamin A/C; both lamin A and C are encoded by LMNA ) are required for heat-shock-mediated transcriptional induction of the Hsp70 gene locus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 1 November 2019
... are transcriptionally upregulated during stress, and importantly, TFs can bind to both promoters and enhancers to regulate stress-induced gene transcription ( Maruyama et al., 2014 ; Vihervaara et al., 2017 ; Grossi et al., 2018 ; Lyu et al., 2018 ). However, the impact of enhancers on genome-wide and stress...
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
... and in cells. Transient interactions detected through BioID link actin to several steps of transcription as well as to RNA processing. Alterations in nuclear actin levels disturb alternative splicing in minigene assays, likely by affecting the transcription elongation rate. This interactome analysis thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs220491.
Published: 7 February 2019
... domains or TADs, antagonize the formation of epigenetically defined but untethered DNA volumes, termed compartments. While condensin complexes formed through cis -interactions must maintain chromatin compaction throughout mitosis, cohesins remain highly dynamic during interphase to allow for transcription...
Journal Articles
J Cell Sci (2019) 132 (3): jcs222729.
Published: 7 February 2019
... associates differently with RNA polymerase II; a gene reporter assay revealed that HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription. Thus, these studies provide the basic clues pertaining to the molecular mechanism by which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... is also regulated by Upf1 at the level of transcription. We first analyzed Arc mRNA and pre-mRNA levels in Upf1 knockdown and KO cells by qRT-PCR and found that these did not differ significantly ( Figs 1 C,D and 2 B–D), strongly suggesting that Arc mRNA is transcriptionally modulated. The Arc...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs210971.
Published: 22 October 2018
...Dennis Klug; Jessica Kehrer; Friedrich Frischknecht; Mirko Singer ABSTRACT Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213967.
Published: 5 June 2018
...-knockdown cells. RANKL-dependent adseverin expression in bone marrow cells was increased by both IL1β (5.4-fold) and TNFα (3.3-fold). Luciferase assays demonstrated that this expression involved transcriptional regulation of the adseverin promoter. Activation of the promoter was restricted to a 1118 bp...
Journal Articles
J Cell Sci (2018) 131 (9): jcs211631.
Published: 8 May 2018
...Grisel Cruz-Becerra; Sarai Valerio-Cabrera; Mandy Juárez; Alyeri Bucio-Mendez; Mario Zurita ABSTRACT In Drosophila , zygotic genome activation occurs in pre-blastoderm embryos during rapid mitotic divisions. How the transcription machinery is coordinated to achieve this goal in a very brief time...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2049–2055.
Published: 15 June 2017
... signalling. Sck2 had the greatest effect on cell growth, and we also show that it significantly increases the cellular transcription rate. These findings indicate, for the first time, that global transcriptional control mediated through S6 kinase signalling is central to cellular growth control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3412–3425.
Published: 15 September 2016
... and activity of the SRF cofactor MAL . Science   316 , 1749 - 1752 . 10.1126/science.1141084 Wang , I.-F. , Chang , H.-Y. and James Shen , C.-K. ( 2006 ). Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition . Exp. Cell Res...
Includes: Supplementary data