... of tenascin-C but was independent of this molecule because capping cells also dispersed after denervation in tenascin-C-null mutant mice. NMJ-capping cells also dispersed after local paralysis with botulinum toxin and in atrophic muscles of transgenic R6/2 mice. We conclude that NMJ-capping cells (proposed...

...A. Scherberich; R. P. Tucker; E. Samandari; M. Brown-Luedi; D. Martin; R. Chiquet-Ehrismann We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins - the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed...

...Martin Flück; Vildan Tunç-Civelek; Matthias Chiquet ABSTRACT Tenascin-C and tenascin-Y are two structurally related extracellular matrix glycoproteins that in many tissues show a complementary expression pattern. Tenascin-C and the fibril-associated minor collagen XII are expressed in tissues...

...Chang Y. Chung; Harold P. Erickson ABSTRACT We have investigated the role of glycosaminoglycans in fibronectin matrix assembly and the incorporation of tenascin-C into matrix fibrils. Chinese hamster ovary cell mutants with a total block in heparan and chondroitin sulfate production failed...

... signaling events are important in the organization and stability of these structures. In previous work, we showed that the counter-adhesive extracellular matrix proteins, thrombospondin, tenascin, and SPARC, induce the disassembly of focal adhesion plaques and we identified the active regions...

...Alf Giese; Melinda A. Loo; Sylvia A. Norman; Sherri Treasurywala; Michael E. Berens ABSTRACT Tenascin, an extracellular matrix protein, is expressed in human gliomas in vitro and in vivo. The distribution of tenascin at the invasive edge of these tumors, even surrounding solitary invading cells...

...Elena I. Deryugina; Mario A. Bourdon ABSTRACT The role of tenascin in mediating tumor cell migration was studied using two cell migration models. In migration/invasion Transwell assays U251.3 glioma cells rapidly migrated through the 8 µm pore size membranes onto tenascinand fibronectin-coated...

.... In the formed tumors the stroma was found to contain mesenchymal extracellular matrix proteins such as tenascin-C, fibulins-1 and 2 and fibronectin, but no nidogen. Nidogen was confined to basement membranes of tumor blood vessels. Since glucocorticoids have been shown to downregulate tenascin-C expression...

...Sambra D. Redick; Jean E. Schwarzbauer ABSTRACT Tenascin, an extracellular matrix protein that modulates cell adhesion, exists as a unique six-armed structure called a hexabrachion. The human hexabrachion is composed of six identical 320 kDa subunits and the structure is stabilized by inter-subunit...

...Peter Lloyd Jones; Nancy Boudreau; Connie A. Myers; Harold P. Erickson; Mina J. Bissell ABSTRACT The physiological role of tenascin in vivo has remained obscure. Although tenascin is regulated in a stage and tissue-dependent manner, knock-out mice appear normal. When tenascin expression...

... sprouting. Sprouting proceeded normally on control matrices, whereas it was inhibited when the cells were grown on matrices deposited in the presence of xylosides. The composition of the permissive and inhibitory matrices was then analysed. Inhibitory matrices contained reduced levels of tenascin...

... can be affected in a negative way by tenascin-C, an extracellular matrix glycoprotein expressed in a tempo-rally and spacially restricted manner during early mor-phogenesis. Tenascin-R (J1-160/180), consisting of two major isoforms of 160 kDa (tenascin-R 160) and 180 kDa (tenascin-R 180) in mammals...

... in insulin (Ins) or PDGF does not produce cells competent to respond to lactogenic hormones. Here we show that competency for differentiation is due at least in part to the modulation of extracellular matrix components. In particular we have studied laminin and tenascin. EGF alters endogenous laminin...

...Wolfgang J. Rettig; Harold P. Erickson; Anthony P. Albino; Pilar Garin-Chesa ABSTRACT The extracellular matrix protein tenascin (TN) is expressed with precise temporo-spatial patterns during embryonic and fetal development and is induced in healing wounds, inflammatory lesions and solid tumors...

...Bernhard Wehrle-Haller; Matthias Chiquet ABSTRACT The extracellular matrix molecule tenascin is expressed within the developing peripheral nervous system, first by migrating neural crest cells and later by satellite (Schwann precursor) cells at the growing tips of periph-eral nerves. Here we found...

...Paritosh Joshi; Chang-Y. Chung; Ikramuddin Aukhil; Harold P. Erickson ABSTRACT We have found that endothelial cells adhere much more strongly than fibroblasts to domains of tenascin and fibronectin. Endothelial cells adhered weakly, without spreading, to bacterial expression proteins corresponding...

...P. Sriramarao; Markus Mendler; Mario A. Bourdon ABSTRACT Human umbilical vein endothelial cells were found to attach and partially spread on human tenascin. The attachment of endothelial cells to tenascin results in elongated cells with interconnecting processes and is distinct from the flattened...

...Noriko Hiraiwa; Hirokatsu Kida; Teruyo Sakakura; Moriaki Kusakabe ABSTRACT Human cancer cell lines A431 and MCF7, which do not produce tenascin (TN) in vitro, were found to produce TN when injected into nude mice or co-cultured with the embryonic mesenchyme. The TN expression in the developing A431...

... rapidly and without scar formation. The mechanisms underlying these differing processes may be related to the fetal environment, the stage of differentiation of the fetal cells or the ECM deposited in the wound. The spatial and temporal distribution of two components of the ECM, fibronectin and tenascin...

... to the underlying matrix. This steric blocking is not unique to hexabrachion. * Author for correspondence 08 08 1989 31 10 1989 © 1990 by Company of Biologists 1990 hexabrachion tenascin extracellular matrix cell adhesion fibronectin The hexabrachion molecule, also called...