...Xiaohuan Sun; Wenqian Yu; Peter W. Baas; Kazuhito Toyooka; Liang Qiang ABSTRACT Association of tau (encoded by Mapt ) with microtubules causes them to be labile, whereas association of MAP6 with microtubules causes them to be stable. As axons differentiate and grow, tau and MAP6 segregate from one...

..., how netrin-1 (NTN1) regulates MT dynamics in axon turning remains a major unanswered question. Here, we show that the coupling of netrin-1 receptor DCC with tau (MAPT)-regulated MTs is involved in netrin-1-promoted axon attraction. Tau directly interacts with DCC and partially overlaps with DCC...

... explores the prospect of import machinery perturbation as a cause of neurodegeneration instigated by the accumulation of aggregating proteins linked to disease. We found that the aggregation-prone Tau variant (Tau P301L ) reduces the levels of components of the import machinery of the outer (TOM20, encoded...

... independently of its effects on non-muscle myosin II. UNC-45A Microtubules Microtubule lattice Microtubule-destabilizing proteins Tau UNC-45, a highly conserved member of the UCS (UNC-45/CRO1/She4p) family, was discovered in the early 1970s, when mutations in its encoding gene caused...

...Yohan Kim; Guanghao Liu; Chad J. Leugers; Joseph D. Mueller; Meghan B. Francis; Marco M. Hefti; Julie A. Schneider; Gloria Lee ABSTRACT Microtubule-associated protein tau, an integral component of neurofibrillary tangles, interacts with a variety of signaling molecules. Previously, our laboratory...

...Sheng Yi; Qianyan Liu; Xinghui Wang; Tianmei Qian; Hongkui Wang; Guangbin Zha; Jun Yu; Pan Wang; Xiaosong Gu; Dandan Chu; Shiying Li ABSTRACT Tau protein (encoded by the gene microtubule-associated protein tau, Mapt ) is essential for the assembly and stability of microtubule and the functional...

... of the Golgi unexpectedly demonstrated that the intact Golgi ribbon is essential for regulating the mTOR pathway and autophagy. Golgi ribbon Autophagy Golgins mTOR LC3 Tau Golgi fragmentation Neurodegeneration Australian Research Council 10.13039/501100000923 DP160102394...

...Yee Lian Chew; Xiaochen Fan; Jürgen Götz; Hannah R. Nicholas Summary Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2...

... disease (AD). We now report that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-β (Aβ) and tau, the respective building blocks of the insoluble plaques and tangles that accumulate in AD brain. Exposure of cultured wild type (WT) neurons to Aβ oligomers caused CCR and activation of the non...

...Vandana M. Sharma; Joel M. Litersky; Kiran Bhaskar; Gloria Lee The microtubule-associated protein tau interacts with the SH3 domain of non-receptor Src family protein tyrosine kinases. A potential consequence of the SH3 interaction is the upregulation of tyrosine kinase activity. Here we...

...Michelle A. Utton; Wendy J. Noble; Josephine E. Hill; Brian H. Anderton; Diane P. Hanger Tau and α-synuclein are both proteins implicated in the pathology of neurodegenerative disease. Here we have investigated the mechanisms of axonal transport of tau and α-synuclein, because failure of axonal...

...Andrey Samsonov; Jiang-Zhou Yu; Mark Rasenick; Sergey V. Popov Tau is a major microtubule-associated protein which induces bundling and stabilization of axonal microtubules (MTs). To investigate the interaction of tau with MTs in living cells, we expressed GFP-tau fusion protein in cultured Xenopus...

...Gail V. W. Johnson; William H. Stoothoff Tau is a group of neuronal microtubule-associated proteins that are formed by alternative mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. Tau plays a key role in regulating microtubule dynamics, axonal transport...

...Yoshitaka Tatebayashi; Niloufar Haque; Yunn-Chyn Tung; Khalid Iqbal; Inge Grundke-Iqbal Anterograde organelle transport is known to be inhibited by overexpression of the microtubule-associated protein tau in cultured cells. However, the molecular mechanism regulating this function of tau protein...

...Hana N. Dawson; Adriana Ferreira; Michele V. Eyster; Nupur Ghoshal; Lester I. Binder; Michael P. Vitek ABSTRACT Conflicting evidence supports a role for tau as an essential neuronal cytoskeletal protein or as a redundant protein whose function can be fulfilled by other microtubule-associated...

... study, we determined the location of the dephosphorylated form of the microtubule-associated protein tau (dtau) within the growth cones of newly forming axons and examined whether this localization was influenced by the actin cytoskeleton. Following elongation of the initial axon at 2-3 days in vitro...

...Garth F. Hall; Boyang Chu; Gloria Lee; Jun Yao ABSTRACT The intracellular accumulation of tau protein and its aggregation into filamentous deposits is the intracellular hallmark of neurofibrillary degenerative diseases such as Alzheimer’s Disease and familial tauopathies in which tau is now thought...

...B. Trinczek; A. Ebneth; E.-M. Mandelkow; E. Mandelkow ABSTRACT We have performed a real time analysis of fluorescence-tagged vesicle and mitochondria movement in living CHO cells transfected with microtubule-associated protein tau or its microtubule-binding domain. Tau does not alter the speed...

...Gloria Lee; S. Todd Newman; David L. Gard; Hamid Band; Govindaswamy Panchamoorthy ABSTRACT Tau and other microtubule-associated proteins promote the assembly and stabilization of neuronal microtubules. While each microtubule-associated protein has distinct properties, their in vivo roles remain...

...Marie-Thérèse Vanier; Pascal Neuville; Liliane Michalik; Jean-François Launay ABSTRACT Tau is a neuron-specific microtubule-associated protein (MAP) that is required for the development and maintaining neuronal cell polarity. Tau is encoded by a single gene, while its transcript undergoes a complex...