... are kinesin-3 motors that anterogradely transport precursors of synaptic vesicles (pre-SVs) and are degraded at synapses. However, in C. elegans , touch neuron-specific knockdown of the E1 ubiquitin-activating enzyme, uba-1 , leads to UNC-104 accumulation at neuronal ends and synapses. Here, we performed...

...Mohima Mukherjee; Chandramouli Mukherjee; Vinayak Ghosh; Aamna Jain; Souren Sadhukhan; Sushma Dagar; Bhavani Shankar Sahu ABSTRACT Dense core vesicles (DCVs) and synaptic vesicles are specialised secretory vesicles in neurons and neuroendocrine cells, and abnormal release of their cargo...

.... Lipid rafts are involved in the formation of transport vesicles, endocytic vesicles, exocytic vesicles, synaptic vesicles and extracellular vesicles, as well as enveloped viruses. Two mechanisms of how rafts are involved in vesicle formation have been proposed: first, that raft proteins and/or lipids...

...Kyoko Chiba; Tomoki Kita; Yuzu Anazawa; Shinsuke Niwa ABSTRACT Neuronal function depends on axonal transport by kinesin superfamily proteins (KIFs). KIF1A is the molecular motor that transports synaptic vesicle precursors, synaptic vesicles, dense core vesicles and active zone precursors. KIF1A...

... (also known as SYN3), is a pivotal regulator of dopamine neuron synaptic function. Here, we show that α-syn interacts with and modulates synapsin III. The absence of α-syn causes a selective increase and redistribution of synapsin III, and changes the organization of synaptic vesicle pools in dopamine...

... of the exocytic machinery, were also recruited onto this compartment. Thus, in neuroendocrine cells, synaptic vesicle and LDCV proteins converge briefly in a distinct trans-Golgi network subcompartment before sorting into SPTVs and LDCVs, ultimately for delivery to the plasma membrane. This specialized sorting...

... decrease sphingolipid and cholesterol levels without greatly affecting the viability of neurons or the expression of synaptic proteins. Electron microscopy showed that the morphology and number of synaptic vesicles in the presynaptic boutons of cholesterol-depleted neurons were similar to those observed...

...Ferdinando Fiumara; Silvia Giovedì; Andrea Menegon; Chiara Milanese; Daniela Merlo; Pier Giorgio Montarolo; Flavia Valtorta; Fabio Benfenati; Mirella Ghirardi Synapsins are synaptic vesicle-associated phosphoproteins involved in the regulation of neurotransmitter release and synapse formation...

... of the rat brain. Strikingly, physiological concentrations of notexin, β-bungarotoxin, taipoxin or textilotoxin induced a dose-dependent formation of discrete bulges at various sites of neuronal projections. Neuronal bulging was paralleled by the redistribution of the two synaptic vesicle markers...

...R. B. Kelly; Frank Bonzelius; Ann Cleves; Lois Clift-O’Grady; Eric Grote; Gary Herman ABSTRACT The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information...

... are being addressed. * To whom correspondence should be addressed © The Company of Biologists Limited 1991 1991 kinesin membrane-bounded organelles immunocytochemistry synaptic vesicles mitochondria microtubules light chains isoforms Perfusion of a nonhydrolyzable analogue...

... © 1990 by Company of Biologists 1990 PC12 human growth hormone synaptophysin packaging secretion synaptic vesicles co-localization intracellular transport regulated secretion. The neuroendocrine cell line PC 12 ( Greene and Tischler, 1976 ) exhibits both regulated...