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Keywords: stem cells
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J Cell Sci (2024) 137 (4): jcs261655.
Published: 23 February 2024
... into pluripotent stem cells, which have the ability to generate all other types of cells and tissues of a given organism. Cellular reprogramming is thus a complex process that requires extensive modification at the epigenetic and transcriptional level, unlocking cellular programs that allow cells to acquire...
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Cell cycle , Metabolism
J Cell Sci (2023) 136 (16): jcs260787.
Published: 15 August 2023
..., including spores, oocytes and adult stem cells. We begin by defining quiescent cells and discussing their roles in key biological processes. We then examine metabolic factors that influence cellular quiescence in both healthy and disease contexts, and how these could be leveraged in the treatment of cancer...
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J Cell Sci (2022) 135 (10): jcs259329.
Published: 20 May 2022
... in specific cells ( Visvader, 2011 ; Gilbertson, 2011 ; Skibinski and Kuperwasser, 2015 ). A hierarchy exists in the mammary epithelium where embryonic bipotent mammary epithelial stem cells (MaSCs) generate unipotent luminal and basal progenitors that are responsible for the generation and maintenance...
Includes: Supplementary data
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J Cell Sci (2022) 135 (9): jcs259304.
Published: 13 May 2022
... application of electric stimulation enables cellular plasticity and the re-establishment of stem cell activity in tissues damaged by ionizing radiation. We show that subthreshold direct current stimulation (DCS) rapidly restores pluripotent stem cell populations previously eliminated by lethally γ-irradiated...
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J Cell Sci (2020) 133 (12): jcs242297.
Published: 19 June 2020
... in PDGFRα + fibroblasts and suggests that this mechanism could be targeted in tissue repair and regeneration. * Present address: Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. § Present address: Fundación Ciencia...
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Metabolism
J Cell Sci (2020) 133 (10): jcs239467.
Published: 27 May 2020
... consumption. Furthermore, Smed-Sirt-1(RNAi) animals displayed reduced cell death and increased stem cell proliferation accompanied by impaired expression of intestinal lineage progenitors and reduced branching of the gut. Taken together, our findings indicate that Sirtuin-1 is a crucial metabolic hub capable...
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J Cell Sci (2019) 132 (16): jcs230276.
Published: 15 August 2019
..., the central pathology of cardiovascular disease. Stem cell technology will revolutionise regenerative medicine, but a need remains to understand key mechanisms of vascular differentiation. RNA-binding proteins have emerged as novel post-transcriptional regulators of alternative splicing and we have previously...
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J Cell Sci (2017) 130 (12): 2018–2025.
Published: 15 June 2017
... known as ESR1) and/or AREG signaling were necessary for non-mammary cell redirection, we inoculated either ERα −/− or AREG −/− mammary cells with non-mammary progenitor cells (WAP-Cre/Rosa26LacZ+ male testicular cells or GFP-positive embryonic neuronal stem cells). ERα −/− cells possessed a limited...
Includes: Supplementary data
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J Cell Sci (2016) 129 (20): 3816–3831.
Published: 15 October 2016
... work is properly attributed. Summary: DUX4 underlies pathogenesis in facioscapulohumeral muscular dystrophy. DUX4 acts mainly as a transcriptional activator that inhibits myogenesis by orchestrating a gene expression profile representative of a more stem-cell-like state. DUX4 DUX4c FSHD...
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J Cell Sci (2014) 127 (21): 4543–4548.
Published: 1 November 2014
...Yu Xin Wang; Nicolas A. Dumont; Michael A. Rudnicki ABSTRACT Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem...
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J Cell Sci (2013) 126 (24): 5610–5625.
Published: 15 December 2013
... progenitors that can remain as extracellular-matrix-producing cells or differentiate into adipocytes. * Author for correspondence ( [email protected] ) 9 09 2013 © 2013. Published by The Company of Biologists Ltd 2013 Fibroblasts Adipogenesis Stem cells Skeletal muscle Satellite...
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J Cell Sci (2013) 126 (18): 4069–4076.
Published: 15 September 2013
...Swathi Yadlapalli; Yukiko M. Yamashita Summary The immortal strand hypothesis proposes that stem cells retain a template copy of genomic DNA (i.e. an ‘immortal strand’) to avoid replication-induced mutations. An alternative hypothesis suggests that certain cells segregate sister chromatids non...
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J Cell Sci (2013) 126 (14): 3192–3203.
Published: 15 July 2013
....   Development   137 , 3057 – 3066 . 10.1242/dev.046631 Duffy   D. J. , Millane   R. C. , Frank   U. ( 2012 ). A heat shock protein and Wnt signaling crosstalk during axial patterning and stem cell proliferation.   Dev. Biol.   362 , 271 – 281 . 10.1016/j.ydbio.2011.11.014 Ewen...
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J Cell Sci (2012) 125 (13): 3061–3073.
Published: 1 July 2012
...Akiko Mammoto; Tadanori Mammoto; Donald E. Ingber Summary Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at the level of transcription is crucial for embryonic...
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