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Keywords: signal transduction
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Journal Articles
J Cell Sci (2021) 134 (3): jcs248393.
Published: 10 February 2021
... and morphogenesis whose alterations contribute to human disease. Rho GTPase Signal transduction Trio family Cytoskeleton Neurodevelopmental disorders Cell morphogenesis Trio family proteins are key regulators of cell motility and morphogenesis, tissue development, and protein trafficking...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... Differentiation Signal transduction p63, also known as Trp63 (transformation related protein 63), TP63 (tumor protein 63) or AIS (amplified in squamous cell carcinoma), is a member of the p53 family of transcription factors, which also includes p73 ( Botchkarev and Flores, 2014 ; Soares and Zhou, 2018...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (4): jcs226423.
Published: 11 February 2019
... of differentiation 3 (CD3) complex. The spatial organization of the TCR–CD3 complex in the membrane is thought to be a key regulatory element of signal transduction, raising the question of how receptor clustering impacts on TCR triggering. How signal transduction at the TCR–CD3 complex encodes the quality...
Journal Articles
J Cell Sci (2019) 132 (1): jcs222380.
Published: 02 January 2019
... tyrosine kinase that regulates various cell functions. We provide the first evidence that Sp1 regulates c-Abl transcription. Conversely, c-Abl modulates Sp1 via ERK1/2. c-Abl Sp1 Smooth muscle Signal transduction Proliferation c-Abl (Abelson tyrosine kinase, Abl) is a non-receptor...
Journal Articles
J Cell Sci (2018) 131 (11): jcs212910.
Published: 05 June 2018
... to suprachiasmatic nucleus to generate circadian rhythms. Opn4 is also present in other non-image-forming visual pathway structures, including the intergeniculate leaflet and olivary pretectal ( Beaulé et al., 2003 ). Melanopsin Opn4 Retinal GPCR G protein Signal transduction Opsin Summary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs209353.
Published: 29 January 2018
... for signal transduction. We further discuss how signaling specificities are maintained through modules at which signals converge, with a focus on SERK-mediated receptor signaling. * Authors for correspondence ( lshan@tamu.edu ; xzmeng@shu.edu.cn ) Competing interests The authors declare...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2018) 131 (1): jcs211367.
Published: 04 January 2018
... by Smo dysregulation ( Pak and Segal, 2016 ). ESCRT Hh Smo Vps20 Vps32 Signal transduction Highlighted Article: The interruption of the intracellular trafficking of Smo before it undergoes lysosome-mediated degradation leads to a high level of Smo accumulation, which is activated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2808–2820.
Published: 01 September 2017
..., ShcD promotes stimulus-independent phosphorylation, ubiquitylation, and internalisation of the EGFR, thereby altering cellular sensitivity to ligand. Signal transduction RTK endocytosis ShcA ShcD EGFR AP2 Clathrin-mediated endocytosis NES Ubiquitin Cbl Proteins of the Src...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2606–2619.
Published: 01 August 2017
... triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development. * Author for correspondence ( schachner@stu.edu.cn ) Competing interests The authors declare...
Journal Articles
J Cell Sci (2017) 130 (14): 2292–2305.
Published: 15 July 2017
.../ Summary: TRPC1 Ca 2+ channels mediate hypoxia-associated cellular events via hypoxia-inducible factor 1-alpha (HIF1α)-dependent and -independent pathways in PTEN-deficient breast cancer cells. Breast cancer Ca 2+ Hypoxia Akt PTEN TRPC1 Signal transduction The microenvironment...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (11): 1929–1939.
Published: 01 June 2017
... , A. , Wollheim , C. B. and Satrustegui , J. ( 2009 ). Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells . J. Biol. Chem.   284 , 515 - 524 . 10.1074/jbc.M806729200 Mukala-Nsengu , A. , Fernández-Pascual , S...
Journal Articles
J Cell Sci (2017) 130 (3): 531–540.
Published: 01 February 2017
... ). Gap junctional regulation of signal transduction in bone cells . FEBS Lett.   588 , 1315 - 1321 . 10.1016/j.febslet.2014.01.025 Buo , A. M. , Williams , M. S. , Kerr , J. P. and Stains , J. P. ( 2016 ). A cost-effective method to enhance adenoviral transduction of primary...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (22): 4175–4189.
Published: 15 November 2016
... CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters. CD36 Receptor and membrane biology Signal transduction Src-family kinase Super-resolution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4642–4652.
Published: 15 December 2015
... and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby...
Journal Articles
J Cell Sci (2015) 128 (22): 4074–4082.
Published: 15 November 2015
... Highlighted Article: The STIM1-interacting protein junctate generates Ca 2+ hotspots that boost phagocytosis independently of STIM1 by promoting Ca 2+ release from ER stores rather than by gating phagosomal Ca 2+ channels. Ca 2+ Capacitive calcium entry Ion channel Junctate Signal transduction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3155–3163.
Published: 15 August 2015
... by The Company of Biologists Ltd 2015 Summary: A new dispensable site in the Kv7.2 channel affects its regulation by CaM, such that its function can be rescued by CaM when one of the other two CaM-interaction sites is impaired. Calmodulin PIP 2 KCNQ M-current Signal transduction Kv7.2...
Journal Articles
J Cell Sci (2015) 128 (12): 2236–2248.
Published: 15 June 2015
... mitochondria function and levels of FOXO1. Vascular biology FOXO1 Signal transduction Development of vascular networks requires paracrine stimulation of the endothelium through VEGF to induce growth and branching, which cannot be accomplished when even a single VEGF allele is ablated ( Ferrara...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 5115–5125.
Published: 01 December 2014
... of differentiated Dictyostelium discoideum cells to investigate whether localized receptor stimuli can induce the spreading of excitable waves in the G-protein-dependent signal transduction system. By imaging the spatiotemporal dynamics of fluorescent markers for phosphatidylinositol (3,4,5)-trisphosphate (PIP 3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4518–4530.
Published: 15 October 2014
....   Nat. Methods   7 , 761 – 768 . 10.1038/nmeth.1493 Matsumoto   T. , Claesson-Welsh   L. ( 2001 ). VEGF receptor signal transduction.   Sci. STKE   2001 , re21 . Morfini   G. A. , Burns   M. , Binder   L. I. , Kanaan   N. M. , LaPointe   N. , Bosco   D...
Includes: Supplementary data