... and a phosphatase (PPase) could serve as the primary regulator. Fig. 6. Atypical MAPK signaling pathways in animals and amoeba. Chemoattractants stimulate G-protein-coupled receptors to activate atypical MAPK signal transduction pathways in amoeba. Question marks signify components that have not been...

.... Rho GTPase Signal transduction Trio family Cytoskeleton Neurodevelopmental disorders Cell morphogenesis Trio family proteins are key regulators of cell motility and morphogenesis, tissue development, and protein trafficking and secretion in numerous biological contexts, including...

... Differentiation Signal transduction Cold Spring Harbor Laboratory 10.13039/100013356 R21OD018332 5F32CA225134-02 5P30CA045508 National Institutes of Health R01CA190997 p63, also known as Trp63 (transformation related protein 63), TP63 (tumor protein 63) or AIS (amplified...

... of differentiation 3 (CD3) complex. The spatial organization of the TCR–CD3 complex in the membrane is thought to be a key regulatory element of signal transduction, raising the question of how receptor clustering impacts on TCR triggering. How signal transduction at the TCR–CD3 complex encodes the quality...

... tyrosine kinase that regulates various cell functions. We provide the first evidence that Sp1 regulates c-Abl transcription. Conversely, c-Abl modulates Sp1 via ERK1/2. c-Abl Sp1 Smooth muscle Signal transduction Proliferation c-Abl (Abelson tyrosine kinase, Abl) is a non-receptor...

...: In addition to its canonical pathway, the photoreceptor melanopsin (Opn4) signals through G proteins βγ and α i and controls several major signaling pathways, which may explain its multi-functionality. Melanopsin Opn4 Retinal GPCR G protein Signal transduction Opsin University of Toledo...

... for signal transduction. We further discuss how signaling specificities are maintained through modules at which signals converge, with a focus on SERK-mediated receptor signaling. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare...

... before it undergoes lysosome-mediated degradation leads to a high level of Smo accumulation, which is activated independently of ligand stimulation. ESCRT Hh Smo Vps20 Vps32 Signal transduction National Institutes of Health 10.13039/100000002 R01 GM079684 P30 CA177558 P30...

... of the EGFR, thereby altering cellular sensitivity to ligand. Signal transduction RTK endocytosis ShcA ShcD EGFR AP2 Clathrin-mediated endocytosis NES Ubiquitin Cbl Proteins of the Src homology and collagen (Shc) family are best characterised as phosphotyrosine adaptors in signal...

... triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development. * Author for correspondence ( [email protected] ) Competing interests The authors declare...

... hypoxia-inducible factor 1-alpha (HIF1α)-dependent and -independent pathways in PTEN-deficient breast cancer cells. Breast cancer Ca 2+ Hypoxia Akt PTEN TRPC1 Signal transduction National Health and Medical Research Council 10.13039/501100000925 569645 1022263 Cancer...

... substrates to achieve precise spatio-temporal control of ubiquitin signals within a specific biological pathway. Deubiquitinase Deubiquitylase Signal transduction Ubiquitylation Medical Research Council 10.13039/501100000265 MC_UU_12016/6 Tenovus 10.13039/501100000723...

... oxygen consumption pathways in pancreatic INS-1E β-cells. (A) Canonical signal transduction pathway of pancreatic β-cells. Metabolism–secretion coupling of β-cells requires the sequential activation of glycolysis, mitochondrial oxidative metabolism and plasma membrane Ca 2+ entry. Glucose stimulates...

... of this domain recapitulates key aspects of Cx43 conditional deletion in bone. Gap junction Osteoblast Osteocyte Signal transduction Intercellular communication Cx43 K258Stop National Institute of Arthritis and Musculoskeletal and Skin Diseases 10.13039/100000069 R01-AR063631 Gap...

... CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters. CD36 Receptor and membrane biology Signal transduction Src-family kinase Super-resolution...

... and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby...

... Highlighted Article: The STIM1-interacting protein junctate generates Ca 2+ hotspots that boost phagocytosis independently of STIM1 by promoting Ca 2+ release from ER stores rather than by gating phagosomal Ca 2+ channels. Ca 2+ Capacitive calcium entry Ion channel Junctate Signal transduction...

... by The Company of Biologists Ltd 2015 Summary: A new dispensable site in the Kv7.2 channel affects its regulation by CaM, such that its function can be rescued by CaM when one of the other two CaM-interaction sites is impaired. Calmodulin PIP 2 KCNQ M-current Signal transduction Kv7.2...

... receptor signal transduction . Sci. STKE   2001 , re21 . 10.1126/stke.2001.112.re21 Mizushima , N. , Yoshimori , T. and Levine , B. ( 2010 ). Methods in mammalian autophagy research . Cell   140 , 313 - 326 . 10.1016/j.cell.2010.01.028 Monvoisin , A. , Alva , J...

... of differentiated Dictyostelium discoideum cells to investigate whether localized receptor stimuli can induce the spreading of excitable waves in the G-protein-dependent signal transduction system. By imaging the spatiotemporal dynamics of fluorescent markers for phosphatidylinositol (3,4,5)-trisphosphate (PIP 3...