... replisomes in agreement with a function in the early maturation of heterochromatin. A high-throughput siRNA screen, supported by mutational and biochemical analyses, identifies SUMO as one regulator of DEK body formation, linking DEK to the complex SUMO protein network that controls chromatin states and cell...

...: We present here the findings of a screen for ion channels regulating cilia in renal cells. The properties of four ion channels suggest a role for membrane subdomains at the base of the cilium. Cilia siRNA screen Patient mutation KCNQ1 KCNJ10 KCNF1 CLCN4 Primary cilia, also...

... by The Company of Biologists Ltd 2014 siRNA screen Mannose 6-phosphate receptor Post-Golgi transport Trafficking Lysosome The lysosomal degradation of endocytosed nutrients, signaling molecules and pathogens or of cytosolic components and organelles turned over by autophagy requires the proper...