... comparisons between plant and animal studies. Autophagy Plant science Regeneration Reprogramming Somatic reprogramming Stem cells Danmarks Frie Forskningsfond http://dx.doi.org/10.13039/501100011958 DFF1-1032-00249B Novo Nordisk Fonden http://dx.doi.org/10.13039/501100009708...

... cues into biochemical and transcriptional adaptation (i.e. mechanotransduction) across tissues. Here, we discuss the recent insights into the roles of hemidesmosomes in age-related tissue regeneration and aging in C. elegans , mice and humans. We highlight the emerging concept of preserved dynamic...

... ROS production and their integration with signaling pathways remain poorly understood. We focused on the early dialog between H 2 O 2 and Sonic hedgehog (Shh) during zebrafish fin regeneration. We demonstrate that H 2 O 2 controls Shh expression and that Shh in turn regulates the H 2 O 2 level via...

...Megha Agarwal; Anushree Bharadwaj; Sam J. Mathew ABSTRACT Muscle stem (satellite) cells express Pax7, a key transcription factor essential for satellite cell maintenance and adult muscle regeneration. We identify the corepressor transducin-like enhancer of split-4 (TLE4) as a Pax7 interaction...

... expression and spatial localization of collagen XI was studied following injury in a Col11a1 inducible knockout mouse model. We found that collagen XI expression occurs during early maturation and is upregulated after stromal injury in areas of regeneration and remodeling. Abnormal fibrillogenesis with new...

...Osvaldo Contreras; Hesham Soliman; Marine Theret; Fabio M. V. Rossi; Enrique Brandan ABSTRACT Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis, tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming growth factor β (TGF-β...

...Annelies Wouters; Jan-Pieter Ploem; Sabine A. S. Langie; Tom Artois; Aziz Aboobaker; Karen Smeets ABSTRACT Pluripotent stem cells hold great potential for regenerative medicine. Increased replication and division, such is the case during regeneration, concomitantly increases the risk of adverse...

... they potentiate osteoblast differentiation and bone formation. Here, we use zebrafish caudal fin regeneration as a model to clarify how the Hippo pathway regulates de novo bone formation and osteoblast differentiation. We demonstrate that Yap inhibition leads to accumulation of osteoprogenitors and prevents...

...Osvaldo Contreras; Meilyn Cruz-Soca; Marine Theret; Hesham Soliman; Lin Wei Tung; Elena Groppa; Fabio M. Rossi; Enrique Brandan ABSTRACT Fibro–adipogenic progenitors (FAPs) are tissue-resident mesenchymal stromal cells (MSCs) required for proper skeletal muscle development, regeneration...

...Francesca Pala; Daniela Di Girolamo; Sébastien Mella; Siham Yennek; Laurent Chatre; Miria Ricchetti; Shahragim Tajbakhsh ABSTRACT During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment...

... valuable tools to increase crop regeneration and transformation efficiency. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 6 7 2017 28 9 2017 © 2018. Published by The Company...

... muscles being more prone to spontaneous regeneration. When the regeneration capacity of the compromised NesKO muscle was tested by muscle injury experiments, a significant healing delay was observed. NesKO satellite cells showed delayed proliferation kinetics in conjunction with an elevation in p35...

... signaling. Wound repair Regeneration Cell migration Epidermis Giant cell Ministry of Education, Science and Technology 10.13039/501100004085 NRF-2012R1A1A2044919 NRF-2015R1A2A2A01006660 Yonsei University 10.13039/501100002573 Cell–cell fusion elicits dramatic...

...Masahiko Takemura; Hiroshi Nakato ABSTRACT Stem cell division is activated to trigger regeneration in response to tissue damage. The molecular mechanisms by which this stem cell mitotic activity is properly repressed at the end of regeneration are poorly understood. Here, we show that a specific...

....) are surgically connected over long periods in order to assess the effect of systemically circulating factors. An important finding from this work is that defective regeneration in aged mice can be attributed to alterations in circulating factors and not a defective intrinsic function ( Conboy et al., 2005...

... and is responsible for muscle regeneration, which is associated with the increased expression of myogenin, desmin and embryonic myosin heavy chain during myogenesis, as well as for myotube formation. In conclusion, NRIP is a novel Z-disc protein that is important for skeletal muscle strength and regenerative...

... cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar...

...-injury-induced regeneration in Sharp-1-deficient mice. We show that embryonic skeletal muscle development is not impaired in the absence of Sharp-1; however, post-natally, the regenerative capacity is compromised. Although the initial phases of injury-induced regeneration proceed normally in Sharp-1...

... of PAK18, modulating PAK function using cell-permeable peptides may be a useful strategy to enhance axon regeneration after injury. PAK is implicated in axon guidance downstream of both attractive and repulsive cues ( Aizawa et al., 2001 ; Fan et al., 2003 ; Lucanic et al., 2006 ; Shekarabi et al...

.... * Author for correspondence ( [email protected] ). 10 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 RNA transport Axon growth Axonal protein synthesis Regeneration Polarized eukaryotic cells transport mRNAs from the nucleus to subcellular domains...