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Keywords: protein degradation
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Journal Articles
In collection:
Proteostasis
J Cell Sci (2023) 136 (19): jcs260930.
Published: 3 October 2023
... and the Cdc48 complex is required for its degradation. The C-terminal transmembrane domain of Bqt4 was necessary and sufficient for proteasome-dependent protein degradation. Accumulation of Bqt4 at the INM impaired cell viability with nuclear envelope deformation, suggesting that quantity control of Bqt4 plays...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (18): jcs241125.
Published: 21 September 2023
.... , Trösch , R. , Töpel , M. , Demiral Sert , T. , Lymperopoulos , P. , Baldwin , A. and Jarvis , R. P. ( 2019 ). Ubiquitin-dependent chloroplast-associated protein degradation in plants . Science 363 , eaav4467 . 10.1126/science.aav4467 Ling , Q. , Sadali , N...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217760.
Published: 5 September 2018
... overcome Hsp70 ablation by increasing misfolded protein degradation. Indeed, RMS13-R cells degraded ERAD substrates more rapidly than RMS cells and induced the autophagy pathway. Surprisingly, inhibition of the proteasome or ERAD had no effect on RMS13-R cell survival, but silencing of select autophagy...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
J Cell Sci (2018) 131 (6): jcs210948.
Published: 20 March 2018
... understand the regulation of Hsp70 in chaperone-assisted protein degradation and the quality control pathway. Our findings raise the question of whether proteasome substrates have special biophysical properties that necessitate escorting chaperones for their proteasomal targeting. Indeed, some proteasome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3578–3587.
Published: 15 October 2017
... Fbxl17 binding. Deacetylation on both K200 and K205 by Sirtuin 1 (Sirt1) and acetylation of p300 (EP300) on K205 collaboratively prepare the motif for SCF Fbxl17 binding thereby triggering PRMT1 protein degradation. Pathogen-derived lipopolysaccharide (LPS) downregulates Sirt1 and p300 to protect PRMT1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3187–3196.
Published: 1 September 2015
... polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation. Bag6 Mislocalised proteins Proteasomes Protein degradation TPR Ubiquitylation The ubiquitin-proteasome system (UPS) constitutes a main pathway for protein degradation in eukaryotic cells...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (21): 4728–4739.
Published: 1 November 2014
... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Aggresomes BAG6 Mislocalised membrane proteins Polyubiquitylation Protein degradation Small glutamine-rich tetratricopeptide repeat-containing protein alpha Hydrophobic amino...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3603–3613.
Published: 15 August 2014
... environment containing specific proteins. The mechanisms of integral INM protein degradation are unknown. Here, we investigated the turnover of Asi2, an integral INM protein in Saccharomyces cerevisiae . We report that Asi2 is degraded by the proteasome independently of the vacuole and that it exhibited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3024–3038.
Published: 15 July 2014
... Protein degradation Proteolytic cleavage Chaperone-mediated autophagy TDP-43-positive aggregate TDP-43 proteinopathies TAR DNA-binding protein (TDP-43, also known as TARDBP) is an RNA- and DNA-binding factor with multiple cellular functions ( Baloh, 2011 ; Buratt et al., 2001; Chen-Plotkin et...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5073–5083.
Published: 1 November 2012
... of Biologists Ltd 2012 Arsenic toxicity Protein aggregation Protein degradation Protein folding Yeast References Aguzzi   A. , Rajendran   L. ( 2009 ). The transcellular spread of cytosolic amyloids, prions, and prionoids.   Neuron   64 , 783 – 790 . 10.1016/j.neuron.2009.12.016...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1296–1308.
Published: 1 March 2012
... earlier work demonstrated the possible regulation of the Notch1–RBP-Jk pathway through protein degradation of RBP-Jk; however, the potential regulator for the degradation of RBP-Jk remains to be determined. Here, we report that the expression of endogenous and exogenous RBP-Jk was increased significantly...
Journal Articles
In collection:
Proteostasis
J Cell Sci (2012) 125 (3): 539–548.
Published: 1 February 2012
... A. L. ( 2009 ). S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains . EMBO J. 28 , 1867 - 1877 . Kim Y. , Starostina N. G. , Kipreos E. T. ( 2008 ). The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (1): 113–122.
Published: 1 January 2011
... protein degradation TPX2 The Aurora-A kinase (officially known as Serine/threonine-protein kinase 6) is an important regulator of cell division and acts in several aspects of spindle formation and function (for reviews, see Barr and Gergely, 2007 ; Vader and Lens, 2008 ). The levels of Aurora...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 678–686.
Published: 1 March 2009
.... and Szekely, L. ( 2001 ). Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation. Proc. Natl. Acad. Sci. USA 98 , 1012 -1017. Nijman, S. M., Luna-Vargas, M. P., Velds...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Proteostasis
J Cell Sci (2007) 120 (2): 256–264.
Published: 15 January 2007
...-exposure results in Yap8p stabilization and gene activation. In this way, regulated degradation contributes to Yap8p control. Arsenite Yap8p Ubiquitin-proteasome pathway Protein degradation Yeast * Author for correspondence (e-mail: [email protected] ) 8 11 2006 ©...
Journal Articles