... of endothelial cells with neuraminidase, heparinase, hyaluronidase, chondroitinase or trypsin did not reduce their susceptibility to poly lysine. Inhibition of microtubule or microfilament formation also had no effect on polylysine cytotoxicity, indicating that internalisation of the polymer...

... results were obtained using [ 3 H]thymidine. Neutral or anionic polypeptides of similar M r were without effect. The molar potency of polylysines increased over the range M r 40000–120000, while polylysines of M r(av ; <25 000 had no effect. In the absence of serum, inhibition occurred more rapidly...