... ) 28 4 2011 © 2011. 2011 rRNA synthesis E2F-1 pRb p53 Cell growth Cell proliferation A proliferating cell must increase its own structural and functional components before division to ensure normal-sized daughter cells ( Thomas, 2000 ). In cells stimulated to proliferate...

... HO15.19 cells. The wild-type LT, but not the various pRb or p53 binding defective LT mutants, represses the PDGF β-receptor promoter activity. Moreover, the inability of the LT-mediated repression in the myc -null cells, the Rb -null 3T3 cells, and the Saos-2 cells lacking pRb and p53, indicates that Myc...

...Kristine Bjerve Gützkow; Soheil Naderi; Heidi K. Blomhoff Increased intracellular levels of cAMP, induced by forskolin, lead to permanent G1 arrest of Reh cells. As expected, we observed a rapid dephosphorylation of the retinoblastoma protein (pRB) within 2 hours of forskolin treatment concomitant...

.... Mutational studies have shown that ElA’s oncogenic ability is determined primarily by its ability to bind to certain cellular proteins and interfere with their function. One of these cellular targets for E1A is the product of the retinoblastoma tumor suppressor gene, pRB. pRB is a negative regulator of cell...